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HSD11B1 hydroxysteroid 11-beta dehydrogenase 1 [ Felis catus (domestic cat) ]

Gene ID: 100529248, updated on 17-Aug-2024

Summary

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Official Symbol
HSD11B1
Official Full Name
hydroxysteroid 11-beta dehydrogenase 1
Primary source
VGNC:VGNC:67654
See related
EnsemblRapid:ENSFCTG00005003866
Gene type
protein coding
RefSeq status
MODEL
Organism
Felis catus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
Orthologs
human mouse all
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Genomic context

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See HSD11B1 in Genome Data Viewer
Location:
chromosome: F1
Exon count:
11
Annotation release Status Assembly Chr Location
105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) F1 NC_058384.1 (33121402..33176474, complement)
104 previous assembly Felis_catus_9.0 (GCF_000181335.3) F1 NC_018739.3 (35325909..35380838, complement)

Chromosome F1 - NC_058384.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC109495657 Neighboring gene interferon regulatory factor 6 Neighboring gene chromosome F1 C1orf74 homolog Neighboring gene TRAF3 interacting protein 3 Neighboring gene uncharacterized LOC123382707 Neighboring gene laminin subunit beta 3 Neighboring gene G0/G1 switch 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Effect of hyperlipidemia on 11β-hydroxysteroid-dehydrogenase, glucocorticoid receptor, and leptin expression in insulin-sensitive tissues of cats. Sieber-Ruckstuhl NS, et al. Domest Anim Endocrinol, 2010 Nov. PMID 20688460

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. study concludes hyperlipidemia has a profound effect on 11beta-hydroxysteroid dehydrogenase expression and supports the connection between high lipid concentrations and tissue cortisol metabolism
    Title: Effect of hyperlipidemia on 11β-hydroxysteroid-dehydrogenase, glucocorticoid receptor, and leptin expression in insulin-sensitive tissues of cats.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 11-beta-hydroxysteroid dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables steroid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in steroid catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
corticosteroid 11-beta-dehydrogenase isozyme 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference F.catus_Fca126_mat1.0 Primary Assembly

Genomic

  1. NC_058384.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

    Range
    33121402..33176474 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006942809.4 → XP_006942871.1  corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X2

    Conserved Domains (1) summary
    cd05332
    Location:2 → 247
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

  2. XM_006942808.4 → XP_006942870.1  corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X1

    See identical proteins and their annotated locations for XP_006942870.1

    UniProtKB/TrEMBL
    M3X6E3
    Conserved Domains (1) summary
    cd05332
    Location:32 → 277
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

  3. XM_019821878.3 → XP_019677437.1  corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X2

    Conserved Domains (1) summary
    cd05332
    Location:2 → 247
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

  4. XM_019821876.3 → XP_019677435.1  corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X1

    UniProtKB/TrEMBL
    M3X6E3
    Conserved Domains (1) summary
    cd05332
    Location:32 → 277
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

  5. XM_045049143.1 → XP_044905078.1  corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X1

    UniProtKB/TrEMBL
    M3X6E3
    Conserved Domains (1) summary
    cd05332
    Location:32 → 277
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

  6. XM_019821875.3 → XP_019677434.1  corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X1

    UniProtKB/TrEMBL
    M3X6E3
    Conserved Domains (1) summary
    cd05332
    Location:32 → 277
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

  7. XM_019821874.3 → XP_019677433.1  corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X1

    UniProtKB/TrEMBL
    M3X6E3
    Related
    ENSFCTP00005006452.1, ENSFCTT00005010394.1
    Conserved Domains (1) summary
    cd05332
    Location:32 → 277
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

  8. XM_019821872.3 → XP_019677431.1  corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X1

    UniProtKB/TrEMBL
    M3X6E3
    Conserved Domains (1) summary
    cd05332
    Location:32 → 277
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

  9. XM_003999332.6 → XP_003999381.1  corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X1

    See identical proteins and their annotated locations for XP_003999381.1

    UniProtKB/TrEMBL
    M3X6E3
    Conserved Domains (1) summary
    cd05332
    Location:32 → 277
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

  10. XM_019821880.3 → XP_019677439.1  corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X4

    Conserved Domains (1) summary
    cl25409
    Location:32 → 221
    SDR; Short-chain dehydrogenases/reductases (SDR)

  11. XM_019821879.3 → XP_019677438.1  corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X3

    Conserved Domains (1) summary
    cl25409
    Location:32 → 220
    SDR; Short-chain dehydrogenases/reductases (SDR)
Nucleotide Protein
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