CORO7-PAM16 CORO7-PAM16 readthrough [Homo sapiens (human)] - Gene

Summary

Official Symbol: CORO7-PAM16provided by HGNC
Official Full Name: CORO7-PAM16 readthroughprovided by HGNC
Primary source: HGNC:HGNC:44424
See related: Ensembl:ENSG00000103426 AllianceGenome:HGNC:44424
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: Crn7; CORO7; Coronin-7
Summary: This locus represents naturally occurring read-through transcription between the neighboring CORO7 (coronin 7) and PAM16 (presequence translocase-associated motor 16) genes on chromosome 16. The read-through transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Jan 2011]
Expression: Broad expression in bone marrow (RPKM 21.4), spleen (RPKM 16.2) and 24 other tissues See more
Orthologs: all
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Genomic context

Location:: 16p13.3

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (4340251..4416596, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (4367543..4445792, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (4390252..4466597, complement)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D6S1566 (e-PCR), detects polymorphism
- UniSTS:9403

MARC_3453-3454:996679102:1 (e-PCR)
- UniSTS:269253

WI-11319 (e-PCR)
- UniSTS:47307

General protein information

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Preferred Names: CORO7-PAM16 protein

Names: 70 kDa WD repeat tumor rejection antigen homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001201479.2 → NP_001188408.1 CORO7-PAM16 protein

Status: VALIDATED

Source sequence(s)

AC012676, BC032732

UniProtKB/TrEMBL

A0A0A6YYL4, B4DKU9

Related

ENSP00000460885.1, ENST00000572467.5

Conserved Domains (5) summary

pfam03656
Location:925 → 1048

Pam16; Pam16

pfam08953
Location:5 → 60

DUF1899; Domain of unknown function (DUF1899)

pfam16300
Location:808 → 852

WD40_4; Type of WD40 repeat

sd00039
Location:81 → 124

7WD40; WD40 repeat [structural motif]

cl02567
Location:546 → 704

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...