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HGF hepatocyte growth factor [ Sus scrofa (pig) ]

Gene ID: 100525120, updated on 8-Mar-2024

Summary

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Official Symbol
HGFprovided by VGNC
Official Full Name
hepatocyte growth factorprovided by VGNC
Primary source
VGNC:VGNC:88869
See related
Ensembl:ENSSSCG00000015403
Gene type
protein coding
RefSeq status
MODEL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Broad expression in spleen (RPKM 7.5), lung (RPKM 3.6) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See HGF in Genome Data Viewer
Location:
chromosome: 9
Exon count:
19
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 9 NC_010451.4 (98437771..98513573)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 9 NC_010451.3 (108765929..108841386)

Chromosome 9 - NC_010451.4Genomic Context describing neighboring genes Neighboring gene calcium voltage-gated channel auxiliary subunit alpha2delta 1 Neighboring gene uncharacterized LOC110262242 Neighboring gene uncharacterized LOC110255496 Neighboring gene histone H3-like Neighboring gene semaphorin 3C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Combined administration of mesenchymal stem cells overexpressing IGF-1 and HGF enhances neovascularization but moderately improves cardiac regeneration in a porcine model. Gómez-Mauricio G, et al. Stem Cell Res Ther, 2016 Jul 16. PMID 27423905, Free PMC Article
  2. Endogenous cardiac stem cell activation by insulin-like growth factor-1/hepatocyte growth factor intracoronary injection fosters survival and regeneration of the infarcted pig heart. Ellison GM, et al. J Am Coll Cardiol, 2011 Aug 23. PMID 21723061

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Combined administration of mesenchymal stem cells overexpressing IGF-1 and HGF enhances neovascularization but moderately improves cardiac regeneration in a porcine model.
    Title: Combined administration of mesenchymal stem cells overexpressing IGF-1 and HGF enhances neovascularization but moderately improves cardiac regeneration in a porcine model.
  2. In an animal model of acute myocardial infarction relevant to human disease, intracoronary administration of IGF-1/hepatocyte growth factor (HGF) is a practical and effective strategy to reduce pathological cardiac remodeling.
    Title: Endogenous cardiac stem cell activation by insulin-like growth factor-1/hepatocyte growth factor intracoronary injection fosters survival and regeneration of the infarcted pig heart.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in hepatocyte growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
hepatocyte growth factor

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010451.4 Reference Sscrofa11.1 Primary Assembly

    Range
    98437771..98513573
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005667687.3 → XP_005667744.2  hepatocyte growth factor isoform X2

    UniProtKB/TrEMBL
    A0A8D0NV73
    Conserved Domains (4) summary
    smart00020
    Location:573 → 797
    Tryp_SPc; Trypsin-like serine protease
    smart00130
    Location:289 → 367
    KR; Kringle domain
    cd00108
    Location:381 → 463
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00129
    Location:124 → 206
    PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...

  2. XM_013979787.2 → XP_013835241.2  hepatocyte growth factor isoform X1

    UniProtKB/TrEMBL
    A0A8D0NV73, A0A8D1V606
    Conserved Domains (4) summary
    smart00020
    Location:578 → 802
    Tryp_SPc; Trypsin-like serine protease
    smart00130
    Location:294 → 372
    KR; Kringle domain
    cd00108
    Location:386 → 468
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00129
    Location:124 → 206
    PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...

  3. XM_003130222.5 → XP_003130270.1  hepatocyte growth factor isoform X3

    UniProtKB/TrEMBL
    A0A480SZ19, A0A4X1SJC0, A0A8D0J077, A0A8D1L7H2, A0A8D1ZAW9, F1SB93
    Conserved Domains (4) summary
    smart00020
    Location:494 → 718
    Tryp_SPc; Trypsin-like serine protease
    smart00130
    Location:210 → 288
    KR; Kringle domain
    cd00108
    Location:302 → 384
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00129
    Location:40 → 122
    PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...

  4. XM_021063485.1 → XP_020919144.1  hepatocyte growth factor isoform X3

    UniProtKB/TrEMBL
    A0A480SZ19, A0A4X1SJC0, A0A8D0J077, A0A8D1L7H2, A0A8D1ZAW9, F1SB93
    Related
    ENSSSCP00000016330.5, ENSSSCT00000016778.5
    Conserved Domains (4) summary
    smart00020
    Location:494 → 718
    Tryp_SPc; Trypsin-like serine protease
    smart00130
    Location:210 → 288
    KR; Kringle domain
    cd00108
    Location:302 → 384
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00129
    Location:40 → 122
    PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...

  5. XM_021063486.1 → XP_020919145.1  hepatocyte growth factor isoform X4

    UniProtKB/TrEMBL
    A0A287BRN0, A0A8D1L7H2, A0A8D1PS51, A0A8D1ZAW9
    Related
    ENSSSCP00000058781.3, ENSSSCT00000065643.3
    Conserved Domains (4) summary
    smart00020
    Location:489 → 713
    Tryp_SPc; Trypsin-like serine protease
    smart00130
    Location:205 → 283
    KR; Kringle domain
    cd00108
    Location:297 → 379
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00129
    Location:40 → 122
    PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
Nucleotide Protein
Heading Accession and Version

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