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PIKFYVE phosphoinositide kinase, FYVE-type zinc finger containing [ Sus scrofa (pig) ]

Gene ID: 100521692, updated on 17-Aug-2024

Summary

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Official Symbol
PIKFYVEprovided by VGNC
Official Full Name
phosphoinositide kinase, FYVE-type zinc finger containingprovided by VGNC
Primary source
VGNC:VGNC:96023
See related
Ensembl:ENSSSCG00000016147
Gene type
protein coding
RefSeq status
MODEL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Ubiquitous expression in kidney (RPKM 5.9), lung (RPKM 3.9) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See PIKFYVE in Genome Data Viewer
Location:
chromosome: 15
Exon count:
44
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 15 NC_010457.5 (111372148..111468720)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 15 NC_010457.4 (122893751..122991762)

Chromosome 15 - NC_010457.5Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110257036 Neighboring gene chromosome 15 C2orf80 homolog Neighboring gene isocitrate dehydrogenase (NADP(+)) 1 Neighboring gene parathyroid hormone 2 receptor Neighboring gene gamma-crystallin F

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. PEDE (Pig EST Data Explorer) has been expanded into Pig Expression Data Explorer, including 10 147 porcine full-length cDNA sequences. Uenishi H, et al. Nucleic Acids Res, 2007 Jan. PMID 17145712, Free PMC Article
  2. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-phosphate 5-kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
1-phosphatidylinositol 3-phosphate 5-kinase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010457.5 Reference Sscrofa11.1 Primary Assembly

    Range
    111372148..111468720
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_013984435.2 → XP_013839889.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X1

    UniProtKB/TrEMBL
    A0A480WFH1
    Conserved Domains (5) summary
    cd00139
    Location:1784 → 2097
    PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
    cd03334
    Location:629 → 889
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cd04448
    Location:369 → 450
    DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
    cd15725
    Location:166 → 227
    FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
    cl12013
    Location:1411 → 1458
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  2. XM_021076161.1 → XP_020931820.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X7

    UniProtKB/TrEMBL
    A0A8D0Q1V7, A0A8D0R946, A0A8D1PZC0, F1SST9
    Conserved Domains (4) summary
    cd00139
    Location:1733 → 2030
    PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
    cd03334
    Location:617 → 877
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cd04448
    Location:357 → 438
    DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
    cd15725
    Location:154 → 215
    FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins

  3. XM_021076163.1 → XP_020931822.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X8

    UniProtKB/TrEMBL
    A0A287B0Z0, A0A8D0RHK5, A0A8D0UD85, A0A8D1XN06
    Conserved Domains (4) summary
    cd00139
    Location:1716 → 2029
    PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
    cd03334
    Location:561 → 821
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cd04448
    Location:357 → 438
    DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
    cd15725
    Location:154 → 215
    FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins

  4. XM_021076167.1 → XP_020931826.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X10

    UniProtKB/TrEMBL
    A0A287ANQ9, A0A8D0Q1V0, A0A8D0R8U5, A0A8D1BRZ4
    Related
    ENSSSCP00000045702.2, ENSSSCT00000038596.2
    Conserved Domains (4) summary
    cd00139
    Location:1677 → 1974
    PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
    cd03334
    Location:561 → 821
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cd04448
    Location:357 → 438
    DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
    cd15725
    Location:154 → 215
    FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins

  5. XM_013984437.2 → XP_013839891.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X3

    UniProtKB/TrEMBL
    A0A287BD34, A0A4X1UZ64
    Related
    ENSSSCP00000054023.3, ENSSSCT00000063694.3
    Conserved Domains (5) summary
    cd00139
    Location:1772 → 2085
    PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
    cd03334
    Location:617 → 877
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cd04448
    Location:357 → 438
    DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
    cd15725
    Location:154 → 215
    FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
    cl12013
    Location:1399 → 1446
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  6. XM_021076160.1 → XP_020931819.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X7

    UniProtKB/TrEMBL
    A0A8D0Q1V7, A0A8D0R946, A0A8D1PZC0, F1SST9
    Related
    ENSSSCP00000017106.3, ENSSSCT00000017580.5
    Conserved Domains (4) summary
    cd00139
    Location:1733 → 2030
    PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
    cd03334
    Location:617 → 877
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cd04448
    Location:357 → 438
    DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
    cd15725
    Location:154 → 215
    FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins

  7. XM_021076162.1 → XP_020931821.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X8

    UniProtKB/TrEMBL
    A0A287B0Z0, A0A8D0RHK5, A0A8D0UD85, A0A8D1XN06
    Related
    ENSSSCP00000050089.3, ENSSSCT00000065767.3
    Conserved Domains (4) summary
    cd00139
    Location:1716 → 2029
    PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
    cd03334
    Location:561 → 821
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cd04448
    Location:357 → 438
    DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
    cd15725
    Location:154 → 215
    FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins

  8. XM_021076166.1 → XP_020931825.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X10

    UniProtKB/TrEMBL
    A0A287ANQ9, A0A8D0Q1V0, A0A8D0R8U5, A0A8D1BRZ4
    Conserved Domains (4) summary
    cd00139
    Location:1677 → 1974
    PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
    cd03334
    Location:561 → 821
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cd04448
    Location:357 → 438
    DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
    cd15725
    Location:154 → 215
    FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins

  9. XM_013984434.2 → XP_013839888.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X1

    UniProtKB/TrEMBL
    A0A480WFH1
    Conserved Domains (5) summary
    cd00139
    Location:1784 → 2097
    PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
    cd03334
    Location:629 → 889
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cd04448
    Location:369 → 450
    DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
    cd15725
    Location:166 → 227
    FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
    cl12013
    Location:1411 → 1458
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  10. XM_013984438.2 → XP_013839892.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X4

    UniProtKB/TrEMBL
    A0A8D0Q1V7, A0A8D0R946, A0A8D1HUE6
    Conserved Domains (5) summary
    cd00139
    Location:1745 → 2042
    PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
    cd03334
    Location:629 → 889
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cd04448
    Location:369 → 450
    DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
    cd15725
    Location:166 → 227
    FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
    cl12013
    Location:1411 → 1458
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  11. XM_013984439.2 → XP_013839893.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X5

    UniProtKB/TrEMBL
    A0A8D0RHK5, A0A8D0UD85, A0A8D1PUB7
    Conserved Domains (5) summary
    cd00139
    Location:1728 → 2041
    PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
    cd03334
    Location:573 → 833
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cd04448
    Location:369 → 450
    DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
    cd15725
    Location:166 → 227
    FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
    cl12013
    Location:1355 → 1402
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  12. XM_021076165.1 → XP_020931824.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X9

    UniProtKB/TrEMBL
    A0A8D0Q1V0, A0A8D0R8U5, A0A8D1Q2V9
    Conserved Domains (4) summary
    cd00139
    Location:1689 → 1986
    PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
    cd03334
    Location:573 → 833
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cd04448
    Location:369 → 450
    DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
    cd15725
    Location:166 → 227
    FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins

  13. XM_013984436.2 → XP_013839890.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X2

    UniProtKB/TrEMBL
    A0A480WFH1
    Conserved Domains (5) summary
    cd00139
    Location:1783 → 2096
    PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
    cd03334
    Location:628 → 888
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cd04448
    Location:368 → 449
    DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
    cd15725
    Location:165 → 226
    FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
    cl12013
    Location:1410 → 1457
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  14. XM_013984440.2 → XP_013839894.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X6

    UniProtKB/TrEMBL
    A0A8D0RHK5, A0A8D0UD85
    Conserved Domains (5) summary
    cd00139
    Location:1727 → 2040
    PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
    cd03334
    Location:572 → 832
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cd04448
    Location:368 → 449
    DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
    cd15725
    Location:165 → 226
    FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
    cl12013
    Location:1354 → 1401
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  15. XM_021076168.1 → XP_020931827.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X11

    UniProtKB/TrEMBL
    A0A4X1UZE7, A0A5G2QST3, A0A8D0HY56
    Related
    ENSSSCP00000067196.1, ENSSSCT00000076507.2
    Conserved Domains (2) summary
    cd04448
    Location:369 → 450
    DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
    cd15725
    Location:166 → 227
    FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
Nucleotide Protein
Heading Accession and Version

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