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CASP9 caspase 9 [ Sus scrofa (pig) ]

Gene ID: 100518913, updated on 17-Aug-2024

Summary

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Official Symbol
CASP9provided by VGNC
Official Full Name
caspase 9provided by VGNC
Primary source
VGNC:VGNC:96938
See related
Ensembl:ENSSSCG00000003460
Gene type
protein coding
RefSeq status
MODEL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Ubiquitous expression in spleen (RPKM 6.6), lung (RPKM 5.8) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See CASP9 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
9
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 6 NC_010448.4 (74707597..74730033, complement)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 6 NC_010448.3 (69087179..69111408, complement)

Chromosome 6 - NC_010448.4Genomic Context describing neighboring genes Neighboring gene chymotrypsin C Neighboring gene uncharacterized LOC110261100 Neighboring gene chymotrypsin-like elastase family, member 2A Neighboring gene DnaJ heat shock protein family (Hsp40) member C16 Neighboring gene agmatinase (putative)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. ATP and cytochrome c-dependent activation of caspase-9 during hypoxia in the cerebral cortex of newborn piglets. Delivoria-Papadopoulos M, et al. Neurosci Lett, 2007 Dec 18. PMID 17976908, Free PMC Article
  2. Mechanism of caspase-9 activation during hypoxia in the cerebral cortex of newborn piglets: the role of Src kinase. Delivoria-Papadopoulos M. Neurosci Lett, 2012 Aug 8. PMID 22728821, Free PMC Article
  3. Zearalenone induces apoptosis and necrosis in porcine granulosa cells via a caspase-3- and caspase-9-dependent mitochondrial signaling pathway. Zhu L, et al. J Cell Physiol, 2012 May. PMID 21732350
  4. Mechanism of activation of caspase-9 and caspase-3 during hypoxia in the cerebral cortex of newborn piglets: the role of nuclear Ca2+ -influx. Delivoria-Papadopoulos M, et al. Neurochem Res, 2007 Mar. PMID 17268855
  5. Hypoxia/re-oxygenation injury induces apoptosis of LLC-PK1 cells by activation of caspase-2. Park MS, et al. Pediatr Nephrol, 2007 Feb. PMID 17109142

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We conclude that the hypoxia-induced activation of caspase-9 is mediated by Src kinase.
    Title: Mechanism of caspase-9 activation during hypoxia in the cerebral cortex of newborn piglets: the role of Src kinase.
  2. Results suggest that zearalenone induces apoptosis and necrosis of porcine granulosa cells in a dose-dependent manner via a caspase-3- and caspase-9-dependent mitochondrial pathway.
    Title: Zearalenone induces apoptosis and necrosis in porcine granulosa cells via a caspase-3- and caspase-9-dependent mitochondrial signaling pathway.
  3. The ATP and cytochrome c dependent activation of caspase-9 is increased during hypoxia. The ATP and cytochrome c sites of Apaf-1 that mediate caspase-9 activation are modified during hypoxia.
    Title: ATP and cytochrome c-dependent activation of caspase-9 during hypoxia in the cerebral cortex of newborn piglets.
  4. Clonidine administration prior to hypoxia prevents the hypoxia-induced increase in the activity of caspases in the cerebral cortex.
    Title: Mechanism of activation of caspase-9 and caspase-3 during hypoxia in the cerebral cortex of newborn piglets: the role of nuclear Ca2+ -influx.
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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity involved in apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cysteine-type endopeptidase activity involved in execution phase of apoptosis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
caspase-9
Names
caspase 9, apoptosis-related cysteine peptidase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010448.4 Reference Sscrofa11.1 Primary Assembly

    Range
    74707597..74730033 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_013998997.2 → XP_013854451.1  caspase-9 isoform X2

    UniProtKB/TrEMBL
    A0A4X1W839, A0A8D0MHK4
    Conserved Domains (2) summary
    cd08326
    Location:5 → 90
    CARD_CASP9; Caspase activation and recruitment domain of Caspase-9
    cd00032
    Location:175 → 407
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

  2. XM_003127618.4 → XP_003127666.1  caspase-9 isoform X1

    UniProtKB/TrEMBL
    A0A4X1W1Y9, A0A8D0MJ65, F1SUV9
    Related
    ENSSSCP00000003758.2, ENSSSCT00000003846.5
    Conserved Domains (2) summary
    cd08326
    Location:5 → 90
    CARD_CASP9; Caspase activation and recruitment domain of Caspase-9
    cd00032
    Location:175 → 437
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
Nucleotide Protein
Heading Accession and Version

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