PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 [Sus scrofa (pig)] - Gene

Summary

Official Symbol: PFKFB3provided by VGNC
Official Full Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3provided by VGNC
Primary source: VGNC:VGNC:96480
See related: Ensembl:ENSSSCG00000011133
Gene type: protein coding
RefSeq status: MODEL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression: Broad expression in subcutaneous adipose (RPKM 41.0), longissimus dorsi muscle (RPKM 24.9) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	10	NC_010452.4 (64776315..64859118, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	10	NC_010452.3 (70831486..70857739)

Chromosome 10 - NC_010452.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables 6-phosphofructo-2-kinase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables fructose-2,6-bisphosphate 2-phosphatase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in fructose 2,6-bisphosphate metabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in fructose metabolic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

NC_010452.4 Reference Sscrofa11.1 Primary Assembly

Range

64776315..64859118 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021065031.1 → XP_020920690.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X6

UniProtKB/TrEMBL

A0A480RIZ0, A0A4X1T883, A0A8D0ZTJ9

Conserved Domains (2) summary

pfam01591
Location:4 → 226

6PF2K; 6-phosphofructo-2-kinase

pfam00300
Location:229 → 415

His_Phos_1; Histidine phosphatase superfamily (branch 1)
XM_013980318.2 → XP_013835772.2 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X2

UniProtKB/TrEMBL

A0A0B8RVM1, A0A287BT84, A0A4X1T822, A0A8D0UKU1

Conserved Domains (2) summary

pfam01591
Location:26 → 246

6PF2K; 6-phosphofructo-2-kinase

pfam00300
Location:249 → 435

His_Phos_1; Histidine phosphatase superfamily (branch 1)
XM_021065030.1 → XP_020920689.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X5

UniProtKB/TrEMBL

A0A8D0R8C9

Conserved Domains (2) summary

pfam01591
Location:26 → 246

6PF2K; 6-phosphofructo-2-kinase

pfam00300
Location:249 → 435

His_Phos_1; Histidine phosphatase superfamily (branch 1)
XM_021065027.1 → XP_020920686.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X3

UniProtKB/TrEMBL

A0A287BM26, A0A287BT84, A0A4X1T822, A0A8D1SDX0

Related

ENSSSCP00000057226.3, ENSSSCT00000040259.3

Conserved Domains (2) summary

pfam01591
Location:26 → 246

6PF2K; 6-phosphofructo-2-kinase

pfam00300
Location:249 → 435

His_Phos_1; Histidine phosphatase superfamily (branch 1)
XM_021065026.1 → XP_020920685.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X1

UniProtKB/TrEMBL

A0A8D1ZX69

Conserved Domains (2) summary

pfam00300
Location:256 → 442

His_Phos_1; Histidine phosphatase superfamily (branch 1)

cl17190
Location:106 → 253

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_021065028.1 → XP_020920687.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X4

UniProtKB/TrEMBL

A0A287A3W2, A0A4X1T6G0, A0A8D0ZTJ9

Conserved Domains (2) summary

pfam01591
Location:1 → 207

6PF2K; 6-phosphofructo-2-kinase

pfam00300
Location:210 → 396

His_Phos_1; Histidine phosphatase superfamily (branch 1)