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RASGRF2 Ras protein specific guanine nucleotide releasing factor 2 [ Sus scrofa (pig) ]

Gene ID: 100515363, updated on 17-Aug-2024

Summary

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Official Symbol
RASGRF2provided by VGNC
Official Full Name
Ras protein specific guanine nucleotide releasing factor 2provided by VGNC
Primary source
VGNC:VGNC:92112
See related
Ensembl:ENSSSCG00000014127
Gene type
protein coding
RefSeq status
MODEL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Ubiquitous expression in subcutaneous adipose (RPKM 1.5), lung (RPKM 1.1) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See RASGRF2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
28
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 2 NC_010444.4 (89525948..89794103)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 2 NC_010444.3 (91513920..91699524)

Chromosome 2 - NC_010444.4Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L27a-like Neighboring gene transfer RNA glutamic acid (anticodon UUC) Neighboring gene mutS homolog 3 Neighboring gene skin secretory protein xP2-like Neighboring gene creatine kinase, mitochondrial 2 Neighboring gene zinc finger CCHC-type containing 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ras-specific guanine nucleotide-releasing factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010444.4 Reference Sscrofa11.1 Primary Assembly

    Range
    89525948..89794103
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021084499.1 → XP_020940158.1  ras-specific guanine nucleotide-releasing factor 2 isoform X1

    UniProtKB/TrEMBL
    A0A8D0TAV7
    Conserved Domains (6) summary
    smart00147
    Location:1001 → 1237
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:904 → 975
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    smart00233
    Location:480 → 588
    PH; Pleckstrin homology domain
    smart00325
    Location:247 → 428
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd13261
    Location:19 → 158
    PH_RasGRF1_2; Ras-specific guanine nucleotide-releasing factors 1 and 2 Pleckstrin homology (PH) domain
    pfam00618
    Location:638 → 686
    RasGEF_N; RasGEF N-terminal motif

  2. XM_021084503.1 → XP_020940162.1  ras-specific guanine nucleotide-releasing factor 2 isoform X5

    UniProtKB/TrEMBL
    A0A5G2QRF4, A0A8D1J8F6
    Conserved Domains (6) summary
    smart00147
    Location:924 → 1160
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:827 → 898
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    smart00233
    Location:403 → 511
    PH; Pleckstrin homology domain
    smart00325
    Location:170 → 351
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam00618
    Location:561 → 609
    RasGEF_N; RasGEF N-terminal motif
    cl17171
    Location:19 → 81
    PH-like; Pleckstrin homology-like domain

  3. XM_021084500.1 → XP_020940159.1  ras-specific guanine nucleotide-releasing factor 2 isoform X2

    UniProtKB/TrEMBL
    A0A480L871, A0A8D0U5P7, A0A8D1J800, F1RF08
    Related
    ENSSSCP00000015022.5, ENSSSCT00000015431.5
    Conserved Domains (6) summary
    smart00147
    Location:1000 → 1236
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:903 → 974
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    smart00233
    Location:480 → 588
    PH; Pleckstrin homology domain
    smart00325
    Location:247 → 428
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd13261
    Location:19 → 158
    PH_RasGRF1_2; Ras-specific guanine nucleotide-releasing factors 1 and 2 Pleckstrin homology (PH) domain
    pfam00618
    Location:638 → 686
    RasGEF_N; RasGEF N-terminal motif

  4. XM_021084501.1 → XP_020940160.1  ras-specific guanine nucleotide-releasing factor 2 isoform X3

    UniProtKB/TrEMBL
    A0A8D0TAV7
    Conserved Domains (6) summary
    smart00147
    Location:986 → 1222
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:889 → 960
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    smart00233
    Location:465 → 573
    PH; Pleckstrin homology domain
    smart00325
    Location:247 → 413
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd13261
    Location:19 → 158
    PH_RasGRF1_2; Ras-specific guanine nucleotide-releasing factors 1 and 2 Pleckstrin homology (PH) domain
    pfam00618
    Location:623 → 671
    RasGEF_N; RasGEF N-terminal motif

  5. XM_021084502.1 → XP_020940161.1  ras-specific guanine nucleotide-releasing factor 2 isoform X4

    UniProtKB/TrEMBL
    A0A286ZWL8
    Conserved Domains (6) summary
    smart00147
    Location:945 → 1181
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:848 → 919
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    smart00233
    Location:424 → 532
    PH; Pleckstrin homology domain
    smart00325
    Location:191 → 372
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam00618
    Location:582 → 630
    RasGEF_N; RasGEF N-terminal motif
    cl17171
    Location:40 → 102
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein
Heading Accession and Version

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