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Zfp518b zinc finger protein 518B [ Mus musculus (house mouse) ]

Gene ID: 100515, updated on 2-Nov-2024

Summary

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Official Symbol
Zfp518bprovided by MGI
Official Full Name
zinc finger protein 518Bprovided by MGI
Primary source
MGI:MGI:2140750
See related
Ensembl:ENSMUSG00000046572 AllianceGenome:MGI:2140750
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf518b; 6820424L24Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human ZNF518B (zinc finger protein 518B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E11.5 (RPKM 6.8), whole brain E14.5 (RPKM 6.7) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp518b in Genome Data Viewer
Location:
5 B3; 5 20.77 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (38825828..38842120, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (38668484..38684984, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6325 Neighboring gene WD repeat domain 1 Neighboring gene predicted gene, 22249 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide D, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_12921 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:39023837-39024020 Neighboring gene STARR-seq mESC enhancer starr_12923 Neighboring gene STARR-seq mESC enhancer starr_12924 Neighboring gene STARR-seq mESC enhancer starr_12927 Neighboring gene predicted gene, 22779 Neighboring gene cytokine-dependent hematopoietic cell linker Neighboring gene STARR-seq mESC enhancer starr_12931

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Functional Proteomic Analysis of Repressive Histone Methyltransferase Complexes Reveals ZNF518B as a G9A Regulator. Maier VK, et al. Mol Cell Proteomics, 2015 Jun. PMID 25680957, Free PMC Article
  2. Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes. Ostapcuk V, et al. Nature, 2018 May. PMID 29795351
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Functional Proteomic Analysis of Repressive Histone Methyltransferase Complexes Reveals ZNF518B as a G9A Regulator
    Title: Functional Proteomic Analysis of Repressive Histone Methyltransferase Complexes Reveals ZNF518B as a G9A Regulator.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 518B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081144.3 → NP_001074613.2  zinc finger protein 518B

    See identical proteins and their annotated locations for NP_001074613.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-5 all encode the same protein.
    Source sequence(s)
    AC093570
    Consensus CDS
    CCDS39078.2
    UniProtKB/Swiss-Prot
    B2RRE4, Q69ZC1
    UniProtKB/TrEMBL
    J3QPN0
    Related
    ENSMUSP00000061753.5, ENSMUST00000057258.11
    Conserved Domains (2) summary
    sd00017
    Location:140 → 160
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13909
    Location:167 → 189
    zf-H2C2_5; C2H2-type zinc-finger domain

  2. NM_001177902.2 → NP_001171373.1  zinc finger protein 518B

    See identical proteins and their annotated locations for NP_001171373.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-5 all encode the same protein.
    Source sequence(s)
    AC093570
    Consensus CDS
    CCDS39078.2
    UniProtKB/Swiss-Prot
    B2RRE4, Q69ZC1
    UniProtKB/TrEMBL
    J3QPN0
    Related
    ENSMUSP00000137381.2, ENSMUST00000179555.8
    Conserved Domains (2) summary
    sd00017
    Location:140 → 160
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13909
    Location:167 → 189
    zf-H2C2_5; C2H2-type zinc-finger domain

  3. NM_001408031.1 → NP_001394960.1  zinc finger protein 518B

    Status: VALIDATED

    Source sequence(s)
    AC093570
    UniProtKB/TrEMBL
    J3QPN0

  4. NM_001408032.1 → NP_001394961.1  zinc finger protein 518B

    Status: VALIDATED

    Source sequence(s)
    AC093570
    UniProtKB/TrEMBL
    J3QPN0

  5. NM_001408033.1 → NP_001394962.1  zinc finger protein 518B

    Status: VALIDATED

    Source sequence(s)
    AC093570
    UniProtKB/TrEMBL
    J3QPN0

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    38825828..38842120 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B2RRE4.1 GenPept UniProtKB/Swiss-Prot:B2RRE4

Gene LinkOut

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