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KCNH6 potassium voltage-gated channel subfamily H member 6 [ Sus scrofa (pig) ]

Gene ID: 100514537, updated on 17-Aug-2024

Summary

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Official Symbol
KCNH6provided by VGNC
Official Full Name
potassium voltage-gated channel subfamily H member 6provided by VGNC
Primary source
VGNC:VGNC:89346
See related
Ensembl:ENSSSCG00000017295
Gene type
protein coding
RefSeq status
MODEL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Low expression observed in reference dataset See more
Orthologs
human mouse all
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Genomic context

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See KCNH6 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
14
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 12 NC_010454.4 (15352765..15374763, complement)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 12 NC_010454.3 (15340202..15361582, complement)

Chromosome 12 - NC_010454.4Genomic Context describing neighboring genes Neighboring gene translational activator of cytochrome c oxidase I Neighboring gene DDB1 and CUL4 associated factor 7 Neighboring gene angiotensin-converting enzyme-like Neighboring gene angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 Neighboring gene uncharacterized LOC110256165

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables inward rectifier potassium channel activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in membrane repolarization during action potential IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of heart rate by cardiac conduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of ventricular cardiac muscle cell membrane repolarization IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
potassium voltage-gated channel subfamily H member 6
Names
potassium voltage-gated channel, subfamily H (eag-related), member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010454.4 Reference Sscrofa11.1 Primary Assembly

    Range
    15352765..15374763 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003131296.4 → XP_003131344.1  potassium voltage-gated channel subfamily H member 6

    UniProtKB/TrEMBL
    A0A5G2QHI3, A0A8D0VCH4
    Related
    ENSSSCP00000061478.1, ENSSSCT00000086864.2
    Conserved Domains (8) summary
    COG0664
    Location:588 → 701
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:594 → 705
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd00130
    Location:41 → 132
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00520
    Location:296 → 520
    Ion_trans; Ion transport protein
    pfam07885
    Location:463 → 517
    Ion_trans_2; Ion channel
    pfam13426
    Location:29 → 132
    PAS_9; PAS domain
    pfam15240
    Location:706 → 815
    Pro-rich; Proline-rich
    pfam15736
    Location:744 → 896
    DUF4684; Domain of unknown function (DUF4684)
Nucleotide Protein
Heading Accession and Version

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