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WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 [ Sus scrofa (pig) ]

Gene ID: 100512012, updated on 17-Aug-2024

Summary

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Official Symbol
WFIKKN2provided by VGNC
Official Full Name
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2provided by VGNC
Primary source
VGNC:VGNC:99105
See related
Ensembl:ENSSSCG00000017557
Gene type
protein coding
RefSeq status
MODEL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Biased expression in ovary (RPKM 18.3) and heart (RPKM 2.5) See more
Orthologs
human mouse all
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Genomic context

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See WFIKKN2 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
3
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 12 NC_010454.4 (27093241..27100423)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 12 NC_010454.3 (27281710..27288914)

Chromosome 12 - NC_010454.4Genomic Context describing neighboring genes Neighboring gene LUC7 like 3 pre-mRNA splicing factor Neighboring gene ANKRD40 C-terminal like Neighboring gene transducer of ERBB2, 1 Neighboring gene uncharacterized LOC110255912

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables receptor antagonist activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transforming growth factor beta binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010454.4 Reference Sscrofa11.1 Primary Assembly

    Range
    27093241..27100423
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_013981059.2 → XP_013836513.2  WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8D1AJZ8
    Conserved Domains (4) summary
    cd05765
    Location:131 → 211
    Ig_3; Subgroup of the immunoglobulin (Ig) superfamily
    cd00104
    Location:45 → 81
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd03575
    Location:362 → 470
    NTR_WFIKKN; NTR domain, WFIKKN subfamily; WFIKKN proteins contain a C-terminal NTR domain and are putative secreted proteins which may be multivalent protease inhibitors that act on serine proteases as well as metalloproteases. Human WFIKKN and a related protein ...
    pfam00014
    Location:292 → 343
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

  2. XM_005668923.3 → XP_005668980.2  WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8D1CYZ3, F1RTB4
    Related
    ENSSSCP00000018606.3, ENSSSCT00000019112.4
    Conserved Domains (5) summary
    cd05765
    Location:228 → 308
    Ig_3; Subgroup of the immunoglobulin (Ig) superfamily
    cd00104
    Location:142 → 178
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd03575
    Location:459 → 567
    NTR_WFIKKN; NTR domain, WFIKKN subfamily; WFIKKN proteins contain a C-terminal NTR domain and are putative secreted proteins which may be multivalent protease inhibitors that act on serine proteases as well as metalloproteases. Human WFIKKN and a related protein ...
    pfam00014
    Location:389 → 440
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam00095
    Location:46 → 93
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
Nucleotide Protein
Heading Accession and Version

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