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C16orf95 chromosome 16 open reading frame 95 [ Homo sapiens (human) ]

Gene ID: 100506581, updated on 8-Mar-2024

Summary

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Official Symbol
C16orf95provided by HGNC
Official Full Name
chromosome 16 open reading frame 95provided by HGNC
Primary source
HGNC:HGNC:40033
See related
Ensembl:ENSG00000260456 AllianceGenome:HGNC:40033
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in testis (RPKM 33.1) and bone marrow (RPKM 1.2) See more
Orthologs
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Genomic context

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Location:
16q24.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (87302814..87317392, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (93373698..93388274, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (87336420..87350998, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928682 Neighboring gene ribosomal protein L39 pseudogene 30 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87312649-87313154 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87329362-87330350 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:87330351-87331337 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:87339626-87340209 Neighboring gene small nucleolar RNA U13 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87348819-87349319 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11320 Neighboring gene C16orf95 divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87364853-87365354 Neighboring gene F-box protein 31 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:87379751-87380306 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87380307-87380861 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87386425-87386966 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:87399801-87400302 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87403399-87404245 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7833 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:87417185-87417838 Neighboring gene uncharacterized LOC124903747 Neighboring gene tRNA-Met (anticodon CAT) 6-1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identifying new associated pleiotropic SNPs with lipids by simultaneous test of multiple longitudinal traits: An Iranian family-based study. Hosseinzadeh N, et al. Gene, 2019 Apr 15. PMID 30658068
  2. Fine expression profiling of full-length transcripts using a size-unbiased cDNA library prepared with the vector-capping method. Oshikawa M, et al. DNA Res, 2008 Jun 30. PMID 18487259, Free PMC Article
  3. The sequence of the human genome. Venter JC, et al. Science, 2001 Feb 16. PMID 11181995
  4. The LIFEdb database in 2006. Mehrle A, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381901, Free PMC Article
  5. From ORFeome to biology: a functional genomics pipeline. Wiemann S, et al. Genome Res, 2004 Oct. PMID 15489336, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: FBXO31

Homology

Clone Names

  • FLJ22477, DKFZp434J1815

General protein information

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Preferred Names
uncharacterized protein C16orf95

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195124.3 → NP_001182053.1  uncharacterized protein C16orf95 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC010531
    Consensus CDS
    CCDS58491.1
    UniProtKB/TrEMBL
    H3BNZ7
    Related
    ENSP00000455079.2, ENST00000567970.2
    Conserved Domains (1) summary
    pfam15132
    Location:76 → 239
    DUF4568; Domain of unknown function (DUF4568)

  2. NM_001195125.3 → NP_001182054.1  uncharacterized protein C16orf95 isoform 2

    See identical proteins and their annotated locations for NP_001182054.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate exons that result in a frameshift in the 3' coding region, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC010531, BC015536, BU839368
    Consensus CDS
    CCDS54049.1
    UniProtKB/Swiss-Prot
    Q9H693
    Related
    ENSP00000253461.4, ENST00000253461.8
    Conserved Domains (1) summary
    pfam15132
    Location:76 → 110
    DUF4568; Domain of unknown function (DUF4568)

  3. NM_001256917.2 → NP_001243846.1  uncharacterized protein C16orf95 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' exon and an alternate start codon, and lacks two exons that result in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (3) shares similarity in the central region but has distinct N- and C-termini and is overall shorter, compared to isoform 1.
    Source sequence(s)
    AB371437, AC010531, BC015536, BI460222, BU839368, DA871621
    Consensus CDS
    CCDS73921.1
    UniProtKB/TrEMBL
    A0A087X224
    Related
    ENSP00000484646.1, ENST00000618367.4
    Conserved Domains (1) summary
    pfam15132
    Location:54 → 95
    DUF4568; Domain of unknown function (DUF4568)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    87302814..87317392 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    93373698..93388274 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H693.1 GenPept UniProtKB/Swiss-Prot:Q9H693

Gene LinkOut

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