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GIRGL glutamine insufficiency regulator of glutaminase lncRNA [ Homo sapiens (human) ]

Gene ID: 100506098, updated on 10-Oct-2023

Summary

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Official Symbol
GIRGLprovided by HGNC
Official Full Name
glutamine insufficiency regulator of glutaminase lncRNAprovided by HGNC
Primary source
HGNC:HGNC:55702
See related
Ensembl:ENSG00000233834 AllianceGenome:HGNC:55702
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MACC1-DT
Expression
Broad expression in small intestine (RPKM 3.7), kidney (RPKM 3.7) and 18 other tissues See more
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Genomic context

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Location:
7p21.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (20217577..20221700)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (20351867..20355990)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (20257200..20261323)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927668 Neighboring gene uncharacterized LOC105375181 Neighboring gene NANOG hESC enhancer GRCh37_chr7:20156449-20156975 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:20159870-20160723 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:20160724-20161576 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:20164991-20165844 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:20165845-20166696 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17988 Neighboring gene MACC1 antisense RNA 1 Neighboring gene MET transcriptional regulator MACC1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25686 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25687 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25688 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:20256832-20258031 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:20259517-20260046 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17989 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25691 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25692 Neighboring gene uncharacterized LOC101927769 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:20369144-20369756 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25693 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25694 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17990 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17991 Neighboring gene ITGB8 antisense RNA 1 Neighboring gene integrin subunit beta 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. LncRNA GIRGL drives CAPRIN1-mediated phase separation to suppress glutaminase-1 translation under glutamine deprivation. Wang R, et al. Sci Adv, 2021 Mar. PMID 33762340, Free PMC Article
  2. Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. Low SK, et al. Cancer Sci, 2013 Aug. PMID 23648065, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Other Names

  • MACC1 divergent transcript

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_134567.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    AI928513, BG777800, DR423379
    Related
    ENST00000688687.1

  2. NR_134568.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site, compared to variant 1.
    Source sequence(s)
    AI928513, BG777800, BI759100
    Related
    ENST00000430859.2

  3. NR_134569.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks a 5' exon and uses an alternate splice site, compared to variant 1.
    Source sequence(s)
    AI928513, BG777800
    Related
    ENST00000439058.6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    20217577..20221700
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    20351867..20355990
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Chemical Information
Molecular Biology Databases