GAPLINC gastric adenocarcinoma associated, positive CD44 regulator, long intergenic non-coding RNA [Homo sapiens (human)] - Gene

Summary

Official Symbol: GAPLINCprovided by HGNC
Official Full Name: gastric adenocarcinoma associated, positive CD44 regulator, long intergenic non-coding RNAprovided by HGNC
Primary source: HGNC:HGNC:51308
See related: Ensembl:ENSG00000266835 AllianceGenome:HGNC:51308
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LINC01540
Expression: Biased expression in placenta (RPKM 2.1), lung (RPKM 1.0) and 7 other tissues See more
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Genomic context

Location:: 18p11.31

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	18	NC_000018.10 (3466250..3478978)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	18	NC_060942.1 (3625722..3638452)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	18	NC_000018.9 (3466248..3478976)

Chromosome 18 - NC_000018.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A conserved long noncoding RNA, GAPLINC, modulates the immune response during endotoxic shock.
Title: A conserved long noncoding RNA, GAPLINC, modulates the immune response during endotoxic shock.
Long non-coding RNA GAPLINC promotes angiogenesis by regulating miR-211 under hypoxia in human umbilical vein endothelial cells.
Title: Long non-coding RNA GAPLINC promotes angiogenesis by regulating miR-211 under hypoxia in human umbilical vein endothelial cells.
Poor expression of long-chain noncoding RNA GAPLINC inhibits epithelial-mesenchymal transition, and invasion and migration of hepatocellular carcinoma cells.
Title: Poor expression of long-chain noncoding RNA GAPLINC inhibits epithelial-mesenchymal transition, and invasion and migration of hepatocellular carcinoma cells.
GAPLINC expression was significantly upregulated in both glioblastoma (GBM) tissues and cell lines. The overexpression of GAPLINC was associated with shorter overall and disease-free survival. GAPLINC silencing suppressed GBM cells proliferation, migration, and invasion, and promoted apoptosis. GAPLINC acted as a competing endogenous RNA to sponge miR-331-3p and knockdown of GAPLINC promoted the expression of miR-331-3p.
Title: LncRNA GAPLINC promotes the growth and metastasis of glioblastoma by sponging miR-331-3p.
Our results suggest that elevated GAPLINC was associated with poor clinical outcomes and might serve as a promising prognostic biomarker in cancer survivors
Title: Clinical usefulness of gastric adenocarcinoma predictive long intergenic noncoding RNA in human malignancies: A meta-analysis.
The in vitro studies showed knockdown of GAPLINC depressed osteosarcoma cell migration and invasion via inhibiting CD44 expression, but no effect on cell proliferation. In conclusion, GAPLINC may serve as a potential biomarker for predicting prognosis and developing therapy for osteosarcoma.
Title: GAPLINC is a predictor of poor prognosis and regulates cell migration and invasion in osteosarcoma.
GAPLINC promotes Non-Small Cell Lung Cancer tumorigenesis by regulating miR-661/eEF2K cascade.
Title: Gastric Adenocarcinoma Predictive Long Intergenic Non-Coding RNA Promotes Tumor Occurrence and Progression in Non-Small Cell Lung Cancer via Regulation of the miR-661/eEF2K Signaling Pathway.
GAPLINC has a role in promoting colorectal cancer invasion via binding to PSF/NONO and partly by stimulating the expression of SNAI2
Title: Long noncoding RNA GAPLINC promotes invasion in colorectal cancer by targeting SNAI2 through binding with PSF and NONO.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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General gene information

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Other Names

RP11-838N2.4
TCONS_00026238
gastric adenocarcinoma predictive long intergenic noncoding RNA
lncRNA-uc002kmd.1
long intergenic non-protein coding RNA 1540

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

NR_110428.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site and is shorter than variant 1.

Source sequence(s)

BM782281, BX107736
NR_110429.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (1) is the longer transcript.

Source sequence(s)

AJ707365, AP001025

Related

ENST00000581442.5