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INAFM2 InaF motif containing 2 [ Homo sapiens (human) ]

Gene ID: 100505573, updated on 3-Nov-2024

Summary

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Official Symbol
INAFM2provided by HGNC
Official Full Name
InaF motif containing 2provided by HGNC
Primary source
HGNC:HGNC:35165
See related
Ensembl:ENSG00000259330 AllianceGenome:HGNC:35165
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OGU1; LINC00984
Summary
Predicted to be located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thyroid (RPKM 12.3), brain (RPKM 7.7) and 25 other tissues See more
Orthologs
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Genomic context

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See INAFM2 in Genome Data Viewer
Location:
15q15.1
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (40323692..40326715)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (38130541..38133587)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (40615893..40618916)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40583508-40584053 Neighboring gene phospholipase C beta 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40584054-40584598 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9239 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:40594309-40595118 Neighboring gene uncharacterized LOC112268152 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:40602266-40602469 Neighboring gene ribosomal protein lateral stalk subunit P0 pseudogene 10 Neighboring gene NANOG hESC enhancer GRCh37_chr15:40613053-40613570 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6323 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6324 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6325 Neighboring gene Sharpr-MPRA regulatory region 6286 Neighboring gene RNA, 5S ribosomal pseudogene 392 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40628805-40629323 Neighboring gene coiled-coil domain containing 9B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40632233-40633036 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40635981-40636480 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40636664-40637261 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40637262-40637858 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40646605-40647130 Neighboring gene proline, histidine and glycine rich 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Interactive associations of the INAFM2 rs67839313 variant and egg consumption with type 2 diabetes mellitus and fasting blood glucose in a Chinese population: A family-based study. Wang X, et al. Gene, 2021 Feb 20. PMID 33333222
  2. Transcripts of unknown function in multiple-signaling pathways involved in human stem cell differentiation. Kikuchi K, et al. Nucleic Acids Res, 2009 Aug. PMID 19531736, Free PMC Article
  3. DSBSO-Based XL-MS Analysis of Breast Cancer PDX Tissues to Delineate Protein Interaction Network in Clinical Samples. Jiao F, et al. J Proteome Res, 2024 Aug 2. PMID 38334954, Free PMC Article
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interactive associations of the INAFM2 rs67839313 variant and egg consumption with type 2 diabetes mellitus and fasting blood glucose in a Chinese population: A family-based study.
    Title: Interactive associations of the INAFM2 rs67839313 variant and egg consumption with type 2 diabetes mellitus and fasting blood glucose in a Chinese population: A family-based study.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ41776, DKFZp762E1314

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative transmembrane protein INAFM2
Names
inaF-motif-containing protein 2
osteogenesis up-regulated transcript 1
osteogenesis upregulating transcript 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301268.2 → NP_001288197.1  putative transmembrane protein INAFM2

    See identical proteins and their annotated locations for NP_001288197.1

    Status: VALIDATED

    Source sequence(s)
    AC013356, AK123770, AL832909, BC036424, BE250750
    Consensus CDS
    CCDS86448.1
    UniProtKB/Swiss-Prot
    P0DMQ5
    Related
    ENSP00000492634.1, ENST00000638170.2
    Conserved Domains (1) summary
    pfam15018
    Location:31 → 63
    InaF-motif; TRP-interacting helix

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    40323692..40326715
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521149.4 → XP_011519451.1  putative transmembrane protein INAFM2 isoform X1

    See identical proteins and their annotated locations for XP_011519451.1

    UniProtKB/Swiss-Prot
    P0DMQ5
    Conserved Domains (1) summary
    pfam15018
    Location:31 → 63
    InaF-motif; TRP-interacting helix

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    38130541..38133587
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054377169.1 → XP_054233144.1  putative transmembrane protein INAFM2 isoform X1

    UniProtKB/Swiss-Prot
    P0DMQ5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0DMQ5.1 GenPept UniProtKB/Swiss-Prot:P0DMQ5

Gene LinkOut

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Molecular Biology Databases
Research Materials