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Prss51 serine protease 51 [ Mus musculus (house mouse) ]

Gene ID: 100504162, updated on 9-Aug-2024

Summary

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Official Symbol
Prss51provided by MGI
Official Full Name
serine protease 51provided by MGI
Primary source
MGI:MGI:1921465
See related
Ensembl:ENSMUSG00000052099 AllianceGenome:MGI:1921465
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700007N14Rik
Summary
Predicted to be active in secretory granule. Orthologous to human PRSS51 (serine protease 51). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 14.7) See more
Orthologs
human all
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Genomic context

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See Prss51 in Genome Data Viewer
Location:
14 D1; 14 33.35 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (64322974..64335123)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (64085525..64097674)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930578I06 gene Neighboring gene predicted gene, 36410 Neighboring gene retinitis pigmentosa 1 homolog like 1 Neighboring gene serine protease 55 Neighboring gene RIKEN cDNA 4930471C04 gene Neighboring gene serine protease 52

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Prss55 but not Prss51 is required for male fertility in mice†. Kobayashi K, et al. Biol Reprod, 2020 Aug 4. PMID 32301961, Free PMC Article
  2. The sperm-associated antigen 6 interactome and its role in spermatogenesis. Liu Y, et al. Reproduction, 2019 Aug. PMID 31146259, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Prss55 but not Prss51 is required for male fertility in micedagger.
    Title: Prss55 but not Prss51 is required for male fertility in mice†.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine protease-like protein 51
Names
protease, serine 51

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193631.1 → NP_001180560.1  serine protease-like protein 51 isoform 1

    See identical proteins and their annotated locations for NP_001180560.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC166997
    Consensus CDS
    CCDS56964.1
    UniProtKB/TrEMBL
    E9PXD1
    Related
    ENSMUSP00000132814.2, ENSMUST00000165710.2
    Conserved Domains (1) summary
    cl21584
    Location:5 → 189
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. NM_001347631.1 → NP_001334560.1  serine protease-like protein 51 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, and uses an alternate splice site in the 5' coding region relative to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK005740, AV172114
    Consensus CDS
    CCDS84145.1
    UniProtKB/TrEMBL
    Q9DAL4
    Related
    ENSMUSP00000066111.6, ENSMUST00000063785.12
    Conserved Domains (1) summary
    cl21584
    Location:40 → 171
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    64322974..64335123
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244872.3 → XP_011243174.1  serine protease-like protein 51 isoform X1

    See identical proteins and their annotated locations for XP_011243174.1

    UniProtKB/TrEMBL
    A0A286YDY8
    Conserved Domains (1) summary
    smart00020
    Location:73 → 296
    Tryp_SPc; Trypsin-like serine protease

  2. XM_006518308.4 → XP_006518371.1  serine protease-like protein 51 isoform X2

    See identical proteins and their annotated locations for XP_006518371.1

    UniProtKB/TrEMBL
    A0A286YDY8
    Conserved Domains (1) summary
    smart00020
    Location:3 → 210
    Tryp_SPc; Trypsin-like serine protease

  3. XM_006518312.1 → XP_006518375.1  serine protease-like protein 51 isoform X3

    See identical proteins and their annotated locations for XP_006518375.1

    UniProtKB/TrEMBL
    E9PXD1
    Conserved Domains (1) summary
    cl21584
    Location:5 → 189
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  4. XM_006518306.4 → XP_006518369.1  serine protease-like protein 51 isoform X1

    See identical proteins and their annotated locations for XP_006518369.1

    UniProtKB/TrEMBL
    A0A286YDY8
    Related
    ENSMUSP00000153617.2, ENSMUST00000224112.2
    Conserved Domains (1) summary
    smart00020
    Location:73 → 296
    Tryp_SPc; Trypsin-like serine protease

  5. XM_030247572.1 → XP_030103432.1  serine protease-like protein 51 isoform X2

    UniProtKB/TrEMBL
    A0A286YDY8
    Conserved Domains (1) summary
    smart00020
    Location:3 → 210
    Tryp_SPc; Trypsin-like serine protease

  6. XM_030247573.1 → XP_030103433.1  serine protease-like protein 51 isoform X4

    UniProtKB/TrEMBL
    Q9DAL4
    Conserved Domains (1) summary
    cl21584
    Location:40 → 171
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  7. XM_030247574.1 → XP_030103434.1  serine protease-like protein 51 isoform X4

    UniProtKB/TrEMBL
    Q9DAL4
    Conserved Domains (1) summary
    cl21584
    Location:40 → 171
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein Strain
Heading Accession and Version

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