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Cbarp calcium channel, voltage-dependent, beta subunit associated regulatory protein [ Mus musculus (house mouse) ]

Gene ID: 100503659, updated on 2-Nov-2024

Summary

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Official Symbol
Cbarpprovided by MGI
Official Full Name
calcium channel, voltage-dependent, beta subunit associated regulatory proteinprovided by MGI
Primary source
MGI:MGI:1354170
See related
Ensembl:ENSMUSG00000035640 AllianceGenome:MGI:1354170
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dos; R29144/1; 9630008F14
Summary
Enables transmembrane transporter binding activity. Involved in negative regulation of calcium ion-dependent exocytosis and negative regulation of voltage-gated calcium channel activity. Located in plasma membrane and secretory granule. Colocalizes with growth cone. Is expressed in nervous system. Orthologous to human CBARP (CACN subunit beta associated regulatory protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in cortex adult (RPKM 40.2), frontal lobe adult (RPKM 40.1) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Cbarp in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79966268..79976189, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80130434..80140355, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_27262 Neighboring gene STARR-positive B cell enhancer ABC_E900 Neighboring gene glutathione peroxidase 4 Neighboring gene strawberry notch 2 Neighboring gene STARR-seq mESC enhancer starr_27263 Neighboring gene STARR-seq mESC enhancer starr_27266 Neighboring gene serine/threonine kinase 11 Neighboring gene STARR-positive B cell enhancer ABC_E11444 Neighboring gene STARR-positive B cell enhancer ABC_E1806 Neighboring gene ATP synthase F1 subunit delta Neighboring gene STARR-seq mESC enhancer starr_27268 Neighboring gene STARR-seq mESC enhancer starr_27269 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:79621397-79621506 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:79622453-79622640 Neighboring gene midnolin Neighboring gene STARR-positive B cell enhancer ABC_E2949 Neighboring gene cold inducible RNA binding protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. α6-Containing Nicotinic Acetylcholine Receptor Reconstitution Involves Mechanistically Distinct Accessory Components. Gu S, et al. Cell Rep, 2019 Jan 22. PMID 30673609
  2. Comprehensive behavioral analysis of voltage-gated calcium channel beta-anchoring and -regulatory protein knockout mice. Nakao A, et al. Front Behav Neurosci, 2015. PMID 26136667, Free PMC Article
  3. Functional α6β4 acetylcholine receptor expression enables pharmacological testing of nicotinic agonists with analgesic properties. Knowland D, et al. J Clin Invest, 2020 Nov 2. PMID 33074244, Free PMC Article
  4. The mouse Peutz-Jeghers syndrome gene Lkb1 encodes a nuclear protein kinase. Smith DP, et al. Hum Mol Genet, 1999 Aug. PMID 10400995
  5. Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry. Zanivan S, et al. J Proteome Res, 2008 Dec. PMID 19367708

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC118572

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transmembrane transporter binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane transporter binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of calcium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of calcium ion-dependent exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of calcium ion-dependent exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of voltage-gated calcium channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
colocalizes_with growth cone IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in secretory granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
voltage-dependent calcium channel beta subunit-associated regulatory protein
Names
downstream of Stk11 protein
protein Dos

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195268.2 → NP_001182197.1  voltage-dependent calcium channel beta subunit-associated regulatory protein isoform 1

    See identical proteins and their annotated locations for NP_001182197.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the supported protein. There are no mouse full-length transcripts representing this exon combination; it is predicted based on partial transcript alignments and homology data. This RefSeq is incomplete at the 5' end due to lack full-length transcript support and splice pattern ambiguity in the 5' UTR.
    Source sequence(s)
    AC159999
    Consensus CDS
    CCDS56734.1
    UniProtKB/Swiss-Prot
    E9QP85, Q497H6, Q66L44, Q8CBL1, Q9QZY3
    Related
    ENSMUSP00000101008.2, ENSMUST00000105369.8
    Conserved Domains (1) summary
    pfam01140
    Location:337 → 394
    Gag_MA; Matrix protein (MA), p15

  2. NM_001421397.1 → NP_001408326.1  voltage-dependent calcium channel beta subunit-associated regulatory protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC159999

  3. NM_001421398.1 → NP_001408327.1  voltage-dependent calcium channel beta subunit-associated regulatory protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC159999

  4. NM_001421399.1 → NP_001408328.1  voltage-dependent calcium channel beta subunit-associated regulatory protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC159999

  5. NM_001421400.1 → NP_001408329.1  voltage-dependent calcium channel beta subunit-associated regulatory protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC159999

  6. NM_001421401.1 → NP_001408330.1  voltage-dependent calcium channel beta subunit-associated regulatory protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC159999

RNA

  1. NR_036582.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' region and includes an additional internal exon, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK137009, BC100552, BM947270
    Related
    ENSMUST00000147778.9

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    79966268..79976189 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512969.3 → XP_006513032.1  voltage-dependent calcium channel beta subunit-associated regulatory protein isoform X1

    See identical proteins and their annotated locations for XP_006513032.1

    UniProtKB/Swiss-Prot
    E9QP85, Q497H6, Q66L44, Q8CBL1, Q9QZY3
    Conserved Domains (1) summary
    pfam01140
    Location:337 → 394
    Gag_MA; Matrix protein (MA), p15

  2. XM_006512970.4 → XP_006513033.1  voltage-dependent calcium channel beta subunit-associated regulatory protein isoform X4

    See identical proteins and their annotated locations for XP_006513033.1

    Conserved Domains (1) summary
    pfam01140
    Location:266 → 323
    Gag_MA; Matrix protein (MA), p15

  3. XM_006512972.4 → XP_006513035.1  voltage-dependent calcium channel beta subunit-associated regulatory protein isoform X4

    See identical proteins and their annotated locations for XP_006513035.1

    Conserved Domains (1) summary
    pfam01140
    Location:266 → 323
    Gag_MA; Matrix protein (MA), p15

  4. XM_006512968.5 → XP_006513031.1  voltage-dependent calcium channel beta subunit-associated regulatory protein isoform X3

    Conserved Domains (1) summary
    pfam01140
    Location:343 → 400
    Gag_MA; Matrix protein (MA), p15

  5. XM_030244790.2 → XP_030100650.1  voltage-dependent calcium channel beta subunit-associated regulatory protein isoform X6

  6. XM_006512976.3 → XP_006513039.1  voltage-dependent calcium channel beta subunit-associated regulatory protein isoform X6

    See identical proteins and their annotated locations for XP_006513039.1

    UniProtKB/Swiss-Prot
    Q66L44
    Conserved Domains (1) summary
    pfam01140
    Location:70 → 127
    Gag_MA; Matrix protein (MA), p15

  7. XM_006512971.5 → XP_006513034.1  voltage-dependent calcium channel beta subunit-associated regulatory protein isoform X4

    See identical proteins and their annotated locations for XP_006513034.1

    Conserved Domains (1) summary
    pfam01140
    Location:266 → 323
    Gag_MA; Matrix protein (MA), p15

  8. XM_030244789.2 → XP_030100649.1  voltage-dependent calcium channel beta subunit-associated regulatory protein isoform X6

  9. XM_006512967.5 → XP_006513030.1  voltage-dependent calcium channel beta subunit-associated regulatory protein isoform X2

    Conserved Domains (1) summary
    pfam01140
    Location:355 → 412
    Gag_MA; Matrix protein (MA), p15

  10. XM_006512973.2 → XP_006513036.2  voltage-dependent calcium channel beta subunit-associated regulatory protein isoform X5

    Conserved Domains (1) summary
    pfam10479
    Location:170 → 313
    FSA_C; Fragile site-associated protein C-terminus

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_015761.2: Suppressed sequence

    Description
    NM_015761.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66L44.4 GenPept UniProtKB/Swiss-Prot:Q66L44

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