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Smim43 small integral membrane protein 43 [ Mus musculus (house mouse) ]

Gene ID: 100503068, updated on 2-Nov-2024

Summary

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Official Symbol
Smim43provided by MGI
Official Full Name
small integral membrane protein 43provided by MGI
Primary source
MGI:MGI:3650339
See related
Ensembl:ENSMUSG00000085007 AllianceGenome:MGI:3650339
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NEMEP; Gm11549
Summary
Enables transmembrane transporter binding activity. Involved in mesendoderm development and positive regulation of D-glucose transmembrane transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cortex adult (RPKM 10.5), frontal lobe adult (RPKM 5.6) and 1 other tissue See more
Orthologs
human all
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Genomic context

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See Smim43 in Genome Data Viewer
Location:
3 B; 3 17.48 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (36569776..36582326, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (36515627..36521412, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1810062G17 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:36375009-36375234 Neighboring gene predicted gene 11548 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene exosome component 9 Neighboring gene cyclin A2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A Nodal enhanced micropeptide NEMEP regulates glucose uptake during mesendoderm differentiation of embryonic stem cells. Fu H, et al. Nat Commun, 2022 Jul 9. PMID 35810171, Free PMC Article
  2. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  3. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  4. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
  5. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane transporter binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in mesendoderm development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of D-glucose transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
small integral membrane protein 43
Names
nodal enhanced mesendoderm micropeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001384269.1 → NP_001371198.1  small integral membrane protein 43

    Status: VALIDATED

    Source sequence(s)
    AC117584
    UniProtKB/Swiss-Prot
    A0A286YD83
    Related
    ENSMUSP00000153318.2, ENSMUST00000124606.3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    36569776..36582326 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162800.1 → XP_036018693.1  small integral membrane protein 43 isoform X1

    UniProtKB/Swiss-Prot
    A0A286YD83

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_040411.2: Suppressed sequence

    Description
    NR_040411.2: This RefSeq was removed because it is now thought that this gene does encode a protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A286YD83.1 GenPept UniProtKB/Swiss-Prot:A0A286YD83

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.