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large1 LARGE xylosyl- and glucuronyltransferase 1 [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 100498555, updated on 14-Nov-2024

Summary

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Official Symbol
large1provided by Xenbase
Official Full Name
LARGE xylosyl- and glucuronyltransferase 1provided by Xenbase
Primary source
Xenbase:XB-GENE-6250446
See related
Ensembl:ENSXETG00000047181 AllianceGenome:Xenbase:XB-GENE-6250446
Gene type
protein coding
RefSeq status
MODEL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as
large; mdc1d
Summary
Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in congenital muscular dystrophy-dystroglycanopathy type A6 and muscular dystrophy-dystroglycanopathy type B6. Orthologous to human LARGE1 (LARGE xylosyl- and glucuronyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See large1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
16
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 3 NC_030679.2 (7076539..7311698)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) Unplaced Scaffold NW_016683631.1 (30447..115076, complement)

Chromosome 3 - NC_030679.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC116409455 Neighboring gene intestine specific homeobox Neighboring gene small nucleolar RNA U3 Neighboring gene small nucleolar RNA U3 Neighboring gene small nucleolar RNA U3 Neighboring gene uncharacterized LOC116409680 Neighboring gene uncharacterized LOC101731742 Neighboring gene synapsin III Neighboring gene TIMP metallopeptidase inhibitor 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables UDP-glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
LARGE xylosyl- and glucuronyltransferase 1
Names
like-glycosyltransferase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030679.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    7076539..7311698
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_031898555.1 → XP_031754415.1  LARGE xylosyl- and glucuronyltransferase 1

    UniProtKB/TrEMBL
    A0A6I8REH9, A0A803KE35
    Related
    ENSXETP00000103607.1, ENSXETT00000117130.1
    Conserved Domains (2) summary
    cd06431
    Location:136 → 415
    GT8_LARGE_C; LARGE catalytic domain has closest homology to GT8 glycosyltransferase involved in lipooligosaccharide synthesis
    pfam13896
    Location:471 → 740
    Glyco_transf_49; Glycosyl-transferase for dystroglycan

  2. XM_031898556.1 → XP_031754416.1  LARGE xylosyl- and glucuronyltransferase 1

    UniProtKB/TrEMBL
    A0A6I8REH9, A0A803KE35
    Related
    ENSXETP00000083362.2, ENSXETT00000080971.2
    Conserved Domains (2) summary
    cd06431
    Location:136 → 415
    GT8_LARGE_C; LARGE catalytic domain has closest homology to GT8 glycosyltransferase involved in lipooligosaccharide synthesis
    pfam13896
    Location:471 → 740
    Glyco_transf_49; Glycosyl-transferase for dystroglycan
Nucleotide Protein Strain
Heading Accession and Version

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