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hic1 hypermethylated in cancer 1 [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 100498001, updated on 4-Nov-2024

Summary

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Official Symbol
hic1provided by Xenbase
Official Full Name
hypermethylated in cancer 1provided by Xenbase
Primary source
Xenbase:XB-GENE-989486
See related
Ensembl:ENSXETG00000023803 AllianceGenome:Xenbase:XB-GENE-989486
Gene type
protein coding
RefSeq status
MODEL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Summary
Predicted to be located in nucleus. Orthologous to human HIC1 (HIC ZBTB transcriptional repressor 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See hic1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
4
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 2 NC_030678.2 (35173310..35190976, complement)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 2 NC_030678.1 (27570722..27588549, complement)

Chromosome 2 - NC_030678.2Genomic Context describing neighboring genes Neighboring gene TSR1, ribosome maturation factor Neighboring gene serine racemase Neighboring gene SMG6 nonsense mediated mRNA decay factor Neighboring gene uncharacterized LOC116408796 Neighboring gene microRNA mir-212 Neighboring gene microRNA mir-132

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The transcription factor Hypermethylated in Cancer 1 (Hic1) regulates neural crest migration via interaction with Wnt signaling. Ray H, et al. Dev Biol, 2020 Jul 15. PMID 32502469, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The transcription factor Hypermethylated in Cancer 1 (Hic1) regulates neural crest migration via interaction with Wnt signaling.
    Title: The transcription factor Hypermethylated in Cancer 1 (Hic1) regulates neural crest migration via interaction with Wnt signaling.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by Xenbase

Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
hypermethylated in cancer 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030678.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    35173310..35190976 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004911637.4 → XP_004911694.1  hypermethylated in cancer 1 protein isoform X3

    UniProtKB/TrEMBL
    A0A6I8R4A6, F7E9T8
    Related
    ENSXETP00000076060.1, ENSXETT00000072080.2
    Conserved Domains (6) summary
    PHA03247
    Location:150 → 385
    PHA03247; large tegument protein UL36; Provisional
    COG5189
    Location:317 → 475
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:485 → 505
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:483 → 505
    zf-C2H2; Zinc finger, C2H2 type
    cd18333
    Location:21 → 141
    BTB_POZ_ZBTB29_HIC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1)
    pfam13465
    Location:525 → 550
    zf-H2C2_2; Zinc-finger double domain

  2. XM_004911636.3 → XP_004911693.1  hypermethylated in cancer 1 protein isoform X2

    UniProtKB/TrEMBL
    A0A6I8RVV4, F7E9T8
    Related
    ENSXETP00000089265.1, ENSXETT00000079452.2
    Conserved Domains (6) summary
    PHA03247
    Location:158 → 393
    PHA03247; large tegument protein UL36; Provisional
    COG5189
    Location:325 → 483
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:493 → 513
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:491 → 513
    zf-C2H2; Zinc finger, C2H2 type
    cd18333
    Location:29 → 149
    BTB_POZ_ZBTB29_HIC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1)
    pfam13465
    Location:533 → 558
    zf-H2C2_2; Zinc-finger double domain

  3. XM_031896677.1 → XP_031752537.1  hypermethylated in cancer 1 protein isoform X1

    UniProtKB/TrEMBL
    A0A803JP40, F7E9T8
    Related
    ENSXETP00000109736.1, ENSXETT00000116327.1
    Conserved Domains (6) summary
    PHA03247
    Location:172 → 407
    PHA03247; large tegument protein UL36; Provisional
    COG5189
    Location:339 → 497
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:507 → 527
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18333
    Location:43 → 163
    BTB_POZ_ZBTB29_HIC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1)
    pfam00096
    Location:505 → 527
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:547 → 572
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version

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