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chrne cholinergic receptor, nicotinic epsilon [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 100497712, updated on 4-Nov-2024

Summary

Official Symbol
chrneprovided by Xenbase
Official Full Name
cholinergic receptor, nicotinic epsilonprovided by Xenbase
Primary source
Xenbase:XB-GENE-979686
See related
Ensembl:ENSXETG00000014957 AllianceGenome:Xenbase:XB-GENE-979686
Gene type
protein coding
RefSeq status
MODEL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Summary
Predicted to enable acetylcholine-gated monoatomic cation-selective channel activity and transmembrane signaling receptor activity. Predicted to act upstream of or within monoatomic ion transmembrane transport. Predicted to be located in postsynaptic membrane. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome; congenital myasthenic syndrome 4A; congenital myasthenic syndrome 4B; and congenital myasthenic syndrome 4C. Orthologous to human CHRNE (cholinergic receptor nicotinic epsilon subunit). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

See chrne in Genome Data Viewer
Location:
chromosome: 3
Exon count:
12
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 3 NC_030679.2 (147415838..147433627, complement)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) Unplaced Scaffold NW_016683461.1 (84384..110736, complement)

Chromosome 3 - NC_030679.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101730300 Neighboring gene estradiol 17-beta-dehydrogenase 12-B-like Neighboring gene Uncharacterized LOC548830 Neighboring gene platelet glycoprotein Ib alpha chain Neighboring gene solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11

Genomic regions, transcripts, and products

General gene information

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables acetylcholine-gated monoatomic cation-selective channel activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
acetylcholine receptor subunit epsilon
Names
cholinergic receptor, nicotinic, epsilon (muscle)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030679.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    147415838..147433627 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_002941821.5XP_002941867.4  acetylcholine receptor subunit epsilon

    UniProtKB/TrEMBL
    A0A6I8RKL1, A0A8J0QTF3
    Related
    ENSXETP00000032716.5, ENSXETT00000032716.5
    Conserved Domains (2) summary
    cd19029
    Location:47241
    LGIC_ECD_nAChR_G; extracellular domain of nicotinic acetylcholine receptor subunit gamma (CHRNG)
    pfam02932
    Location:248491
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region