ampd2 adenosine monophosphate deaminase 2 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: ampd2provided by Xenbase
Official Full Name: adenosine monophosphate deaminase 2provided by Xenbase
Primary source: Xenbase:XB-GENE-982645
See related: Ensembl:ENSXETG00000002009 AllianceGenome:Xenbase:XB-GENE-982645
Gene type: protein coding
RefSeq status: MODEL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Summary: Predicted to enable AMP deaminase activity. Predicted to be involved in AMP metabolic process and IMP biosynthetic process. Predicted to act upstream of or within IMP salvage. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 63 and pontocerebellar hypoplasia type 9. Orthologous to human AMPD2 (adenosine monophosphate deaminase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	2	NC_030678.2 (71685099..71748525)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	2	NC_030678.1 (63318168..63382217)

Chromosome 2 - NC_030678.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables AMP deaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables AMP deaminase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in AMP metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in IMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within IMP salvage	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: AMP deaminase 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

NC_030678.2 Reference UCB_Xtro_10.0 Primary Assembly

Range

71685099..71748525

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_002932984.4 → XP_002933030.2 AMP deaminase 2 isoform X3

UniProtKB/TrEMBL

A0A6I8SCA6, A0A6I8SRY8

Related

ENSXETP00000097544.1, ENSXETT00000076591.2

Conserved Domains (2) summary

cd01319
Location:289 → 785

AMPD; AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.

cl29099
Location:33 → 140

tig; trigger factor; Provisional
XM_031896863.1 → XP_031752723.1 AMP deaminase 2 isoform X1

UniProtKB/TrEMBL

A0A6I8SCA6, A0A8J1J4C7

Conserved Domains (1) summary

cd01319
Location:333 → 829

AMPD; AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.
XM_031896864.1 → XP_031752724.1 AMP deaminase 2 isoform X2

UniProtKB/TrEMBL

A0A6I8SCA6, A0A8J1J4B9

Conserved Domains (1) summary

cd01319
Location:310 → 806

AMPD; AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.
XM_004910662.3 → XP_004910719.1 AMP deaminase 2 isoform X4

UniProtKB/TrEMBL

A0A6I8REL8, A0A6I8S9E7

Related

ENSXETP00000094912.2, ENSXETT00000086459.2

Conserved Domains (1) summary

cd01319
Location:236 → 732

AMPD; AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.