pomt2 protein-O-mannosyltransferase 2 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: pomt2provided by Xenbase
Official Full Name: protein-O-mannosyltransferase 2provided by Xenbase
Primary source: Xenbase:XB-GENE-1006906
See related: Ensembl:ENSXETG00000031515 AllianceGenome:Xenbase:XB-GENE-1006906
Gene type: protein coding
RefSeq status: MODEL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Summary: Predicted to enable dolichyl-phosphate-mannose-protein mannosyltransferase activity. Predicted to act upstream of or within protein O-linked glycosylation. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in lissencephaly and muscular dystrophy (multiple). Orthologous to human POMT2 (protein O-mannosyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	8	NC_030684.2 (82771027..82796979, complement)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	8	NC_030684.1 (61644168..61669415, complement)

Chromosome 8 - NC_030684.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables dolichyl-phosphate-mannose-protein mannosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dolichyl-phosphate-mannose-protein mannosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables mannosyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within protein O-linked glycosylation	IEA Inferred from Electronic Annotation more info
involved_in protein O-linked mannosylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein glycosylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein O-mannosyl-transferase 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

NC_030684.2 Reference UCB_Xtro_10.0 Primary Assembly

Range

82771027..82796979 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_002938863.5 → XP_002938909.2 protein O-mannosyl-transferase 2 isoform X1

UniProtKB/TrEMBL

A0A6I8QLH7

Related

ENSXETP00000073156.1, ENSXETT00000072983.2

Conserved Domains (1) summary

COG1928
Location:49 → 731

PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]
XM_012969186.3 → XP_012824640.1 protein O-mannosyl-transferase 2 isoform X3

UniProtKB/TrEMBL

A0A8J0SWI8

Conserved Domains (1) summary

COG1928
Location:2 → 653

PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]
XM_031892365.1 → XP_031748225.1 protein O-mannosyl-transferase 2 isoform X2

UniProtKB/TrEMBL

A0A8J1ITX9

Conserved Domains (1) summary

COG1928
Location:33 → 696

PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]
XM_004917056.4 → XP_004917113.1 protein O-mannosyl-transferase 2 isoform X4

UniProtKB/TrEMBL

A0A8J0R432

Conserved Domains (4) summary

smart00472
Location:328 → 377

MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases

COG1928
Location:49 → 605

PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]

pfam16192
Location:394 → 603

PMT_4TMC; C-terminal four TMM region of protein-O-mannosyltransferase

cl21590
Location:50 → 132

PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase