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plch2 phospholipase C eta 2 [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 100487353, updated on 4-Nov-2024

Summary

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Official Symbol
plch2provided by Xenbase
Official Full Name
phospholipase C eta 2provided by Xenbase
Primary source
Xenbase:XB-GENE-988591
See related
Ensembl:ENSXETG00000012092 AllianceGenome:Xenbase:XB-GENE-988591
Gene type
protein coding
RefSeq status
MODEL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Summary
Predicted to enable calcium ion binding activity and phosphatidylinositol phospholipase C activity. Predicted to act upstream of or within intracellular signal transduction and lipid catabolic process. Orthologous to human PLCH2 (phospholipase C eta 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See plch2 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
28
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 7 NC_030683.2 (90121660..90487229, complement)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 7 NC_030683.1 (81086652..81206588, complement)

Chromosome 7 - NC_030683.2Genomic Context describing neighboring genes Neighboring gene pantothenate kinase 4 Neighboring gene glutamate ionotropic receptor kainate type subunit 5 like Neighboring gene uncharacterized LOC116412076 Neighboring gene peroxisomal biogenesis factor 10 Neighboring gene retention in endoplasmic reticulum sorting receptor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030683.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    90121660..90487229 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_031905491.1 → XP_031761351.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X2

    UniProtKB/TrEMBL
    A0A6I8SGN2, A0A8J1JXS0
    Conserved Domains (4) summary
    cd00275
    Location:775 → 899
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd13364
    Location:44 → 150
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd16221
    Location:168 → 308
    EFh_PI-PLCeta2; EF-hand motif found in phosphoinositide phospholipase C eta 2 (PI-PLC-eta2)
    cl14615
    Location:320 → 745
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

  2. XM_031905490.1 → XP_031761350.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X1

    UniProtKB/TrEMBL
    A0A6I8SGN2, A0A8J1JWE5
    Conserved Domains (4) summary
    cd00275
    Location:777 → 901
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd13364
    Location:44 → 150
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd16221
    Location:168 → 308
    EFh_PI-PLCeta2; EF-hand motif found in phosphoinositide phospholipase C eta 2 (PI-PLC-eta2)
    cl14615
    Location:320 → 747
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

  3. XM_031905492.1 → XP_031761352.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X4

    UniProtKB/TrEMBL
    A0A6I8SGN2, A0A8J1JTZ0
    Conserved Domains (4) summary
    cd00275
    Location:751 → 875
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd13364
    Location:18 → 124
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd16221
    Location:142 → 282
    EFh_PI-PLCeta2; EF-hand motif found in phosphoinositide phospholipase C eta 2 (PI-PLC-eta2)
    cl14615
    Location:294 → 721
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

  4. XM_018096045.2 → XP_017951534.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X3

    UniProtKB/TrEMBL
    A0A6I8SK15, A0A8J0SVR0
    Related
    ENSXETP00000093533.2, ENSXETT00000095840.2
    Conserved Domains (4) summary
    cd00275
    Location:759 → 883
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd13364
    Location:26 → 132
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd16221
    Location:150 → 290
    EFh_PI-PLCeta2; EF-hand motif found in phosphoinositide phospholipase C eta 2 (PI-PLC-eta2)
    cl14615
    Location:302 → 729
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

  5. XM_031905493.1 → XP_031761353.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X5

    UniProtKB/TrEMBL
    A0A8J1JTY7
    Conserved Domains (4) summary
    cd00275
    Location:777 → 901
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd13364
    Location:44 → 150
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd16221
    Location:168 → 308
    EFh_PI-PLCeta2; EF-hand motif found in phosphoinositide phospholipase C eta 2 (PI-PLC-eta2)
    cl14615
    Location:320 → 747
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
Nucleotide Protein Strain
Heading Accession and Version

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