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MTRNR2L8 MT-RNR2 like 8 (pseudogene) [ Homo sapiens (human) ]

Gene ID: 100463486, updated on 23-Nov-2023

Summary

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Official Symbol
MTRNR2L8provided by HGNC
Official Full Name
MT-RNR2 like 8 (pseudogene)provided by HGNC
Primary source
HGNC:HGNC:37165
See related
AllianceGenome:HGNC:37165
Gene type
pseudo
RefSeq status
INFERRED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HN8
Summary
Predicted to enable receptor antagonist activity. Predicted to be involved in negative regulation of execution phase of apoptosis. Predicted to be located in cytoplasm and extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: It is unclear if this is a transcribed protein-coding gene, or if it is a nuclear pseudogene of the mitochondrial MT-RNR2 gene. [16 Mar 2015]
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Genomic context

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Location:
11p15.4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (10507887..10509176, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (10592362..10593651, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (10529434..10530723, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100130460 Neighboring gene RNA, U6atac small nuclear 33, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:10430364-10430864 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:10430865-10431365 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:10437608-10437821 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4432 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4433 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3150 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3151 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3152 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4434 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4435 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4436 Neighboring gene adenosine monophosphate deaminase 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:10500293-10500792 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:10509586-10510490 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:10521616-10522209 Neighboring gene Sharpr-MPRA regulatory region 11145 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:10532526-10533436 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4437 Neighboring gene microRNA 4485 Neighboring gene ring finger protein 141 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4438 Neighboring gene IRAG1 antisense RNA 1 Neighboring gene lymphatic vessel endothelial hyaluronan receptor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Epigenome-Wide Association Study Indicates Hypomethylation of MTRNR2L8 in Large-Artery Atherosclerosis Stroke. Shen Y, et al. Stroke, 2019 Jun. PMID 31084332
  2. Whole-transcriptome brain expression and exon-usage profiling in major depression and suicide: evidence for altered glial, endothelial and ATPase activity. Pantazatos SP, et al. Mol Psychiatry, 2017 May. PMID 27528462, Free PMC Article
  3. Immunolocalization of humanin in human sperm and testis. Moretti E, et al. Fertil Steril, 2010 Dec. PMID 20542501
  4. Humanin: a novel central regulator of peripheral insulin action. Muzumdar RH, et al. PLoS One, 2009 Jul 22. PMID 19623253, Free PMC Article
  5. The human mitochondrial genome may code for more than 13 proteins. Capt C, et al. Mitochondrial DNA A DNA Mapp Seq Anal, 2016 Sep. PMID 25630734

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. these findings demonstrate that DNA methylation plays an important role in large-artery atherosclerotic stroke and that methylation of MTRNR2L8 is a potential therapeutic target and diagnostic biomarker for stroke.
    Title: Epigenome-Wide Association Study Indicates Hypomethylation of MTRNR2L8 in Large-Artery Atherosclerosis Stroke.
  2. Exploratory whole-exome analysis revealed higher expression of humanin-like 8 (MTRNR2L8, or HN8) in both suicide and depression. Here, increased expression of MRTNR2L8 suggests a compensatory and constitutive up-regulation in response to the chronic stress in Major Depressive Disorder.
    Title: Whole-transcriptome brain expression and exon-usage profiling in major depression and suicide: evidence for altered glial, endothelial and ATPase activity.
  3. Data suggest that humanin (the first small peptide of a putative set of mitochondrial derived peptides) exhibits strong cytoprotective actions against various stress and disease models.
    Title: Humanin: a harbinger of mitochondrial-derived peptides?
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Other Names

  • MT-RNR2 pseudogene 8
  • MTRNR2-like 8
  • humanin-like 8

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables receptor antagonist activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of execution phase of apoptosis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_077258.1 

    Range
    101..1390
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    10507887..10509176 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    10592362..10593651 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001190702.2: Suppressed sequence

    Description
    NM_001190702.2: This RefSeq was removed because it is now thought that this gene does not encode a protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CJ75.1 GenPept UniProtKB/Swiss-Prot:P0CJ75

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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Research Materials
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