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NRG2 neuregulin 2 [ Pongo abelii (Sumatran orangutan) ]

Gene ID: 100432995, updated on 26-Mar-2024

Summary

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Gene symbol
NRG2
Gene description
neuregulin 2
Locus tag
CR201_G0017472
See related
Ensembl:ENSPPYG00000015847
Gene type
protein coding
RefSeq status
MODEL
Organism
Pongo abelii
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo
Orthologs
human mouse all
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Genomic context

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See NRG2 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPonAbe1-v2.0_pri (GCF_028885655.2) 4 NC_071989.2 (148209714..148412838, complement)
RS_2023_04 previous assembly NHGRI_mPonAbe1-v1.1-hic.freeze_pri (GCF_028885655.1) 5 NC_071990.1 (148246855..148449994, complement)

Chromosome 4 - NC_071989.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC129059720 Neighboring gene pleckstrin and Sec7 domain containing 2 Neighboring gene uncharacterized LOC129059721 Neighboring gene uncharacterized LOC129059722 Neighboring gene uncharacterized LOC103890731 Neighboring gene purine rich element binding protein A Neighboring gene IgA inducing protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in animal organ development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
pro-neuregulin-2, membrane-bound isoform

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028885655.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

Genomic

  1. NC_071989.2 Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

    Range
    148209714..148412838 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024247543.3 → XP_024103311.1  pro-neuregulin-2, membrane-bound isoform isoform X3

    UniProtKB/TrEMBL
    A0A2J8VPG5, A0A2J8VPG9, A0A8I5TYX7, A0A8I5UBJ6
    Related
    ENSPPYP00000027503.1
    Conserved Domains (3) summary
    cd05750
    Location:252 → 325
    Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins (NRGs)
    pfam02158
    Location:391 → 826
    Neuregulin; Neuregulin family
    cl28647
    Location:328 → 416
    PHA02887; EGF-like protein; Provisional

  2. XM_024247542.3 → XP_024103310.1  pro-neuregulin-2, membrane-bound isoform isoform X1

    UniProtKB/TrEMBL
    A0A2J8VPF9, A0A2J8VPG5, A0A8I5TYX7, A0A8I5U5L3
    Related
    ENSPPYP00000025033.1
    Conserved Domains (3) summary
    cd05750
    Location:252 → 325
    Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins (NRGs)
    cd00054
    Location:352 → 380
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam02158
    Location:397 → 832
    Neuregulin; Neuregulin family

  3. XM_054556628.2 → XP_054412603.1  pro-neuregulin-2, membrane-bound isoform isoform X2

    UniProtKB/TrEMBL
    A0A2J8VPG1, H2PGR3
Nucleotide Protein
Heading Accession and Version

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