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IGLL5 immunoglobulin lambda like polypeptide 5 [ Homo sapiens (human) ]

Gene ID: 100423062, updated on 19-Mar-2024

Summary

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Official Symbol
IGLL5provided by HGNC
Official Full Name
immunoglobulin lambda like polypeptide 5provided by HGNC
Primary source
HGNC:HGNC:38476
See related
Ensembl:ENSG00000254709 AllianceGenome:HGNC:38476
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IGL; IGLV; VL-MAR
Summary
This gene encodes one of the immunoglobulin lambda-like polypeptides. It is located within the immunoglobulin lambda locus but it does not require somatic rearrangement for expression. The first exon of this gene is unrelated to immunoglobulin variable genes; the second and third exons are the immunoglobulin lambda joining 1 and the immunoglobulin lambda constant 1 gene segments. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Orthologs
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Genomic context

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Location:
22q11.22
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (22887816..22896111)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (23310731..23319020)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (23229996..23238291)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene immunoglobulin lambda locus Neighboring gene uncharacterized LOC105372948 Neighboring gene uncharacterized LOC102724638 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18727 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18728 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18729 Neighboring gene immunoglobulin lambda variable 3-1 Neighboring gene microRNA 5571 Neighboring gene immunoglobulin lambda joining 1 Neighboring gene immunoglobulin lambda constant 1 Neighboring gene immunoglobulin lambda joining 2 Neighboring gene immunoglobulin lambda constant 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. IGLL5 is correlated with tumor-infiltrating immune cells in clear cell renal cell carcinoma. Xia ZN, et al. FEBS Open Bio, 2021 Mar. PMID 33449444, Free PMC Article
  2. Epitope-specific human influenza antibody repertoires diversify by B cell intraclonal sequence divergence and interclonal convergence. Krause JC, et al. J Immunol, 2011 Oct 1. PMID 21880983, Free PMC Article
  3. Utility of Doppler myocardial imaging, cardiac biomarkers, and clonal immunoglobulin genes to assess left ventricular performance and stratify risk following peripheral blood stem cell transplantation in patients with systemic light chain amyloidosis (Al). Bellavia D, et al. J Am Soc Echocardiogr, 2011 Apr. PMID 21315556, Free PMC Article
  4. Soft tissue, joint, and bone manifestations of AL amyloidosis: clinical presentation, molecular features, and survival. Prokaeva T, et al. Arthritis Rheum, 2007 Nov. PMID 17968927
  5. Production and characterization of recombinant human anti-HBs Fab antibodies. Maeda F, et al. J Virol Methods, 2005 Aug. PMID 15896855

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IGLL5 is correlated with tumor-infiltrating immune cells in clear cell renal cell carcinoma.
    Title: IGLL5 is correlated with tumor-infiltrating immune cells in clear cell renal cell carcinoma.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in immunoglobulin mediated immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of IgG immunoglobulin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular exosome HDA PubMed 

General protein information

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Preferred Names
immunoglobulin lambda-like polypeptide 5
Names
G lambda-1
anti HBs antibody light-chain Fab fragment
anti-SARS-CoV-2 immunoglobulin light chain
germline immunoglobulin lambda 1
immunoglobin anti-granzymeB light chain variable region
immunoglobulin lambda 1 light chain
immunoglobulin lambda 2 light chain
immunoglobulin lambda 3 light chain
immunoglobulin lambda chain
immunoglobulin lambda light chain variable region
immunoglobulin lambda-3 surrogate light chain
immunoglobulin light chain variable region EM1-PPS-4-L1-1
omega light chain protein 14.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_000002.1 

    Range
    853944..861998
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178126.2 → NP_001171597.1  immunoglobulin lambda-like polypeptide 5 isoform 1

    See identical proteins and their annotated locations for NP_001171597.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA847784, AC245028, AJ318022, BG756003
    Consensus CDS
    CCDS54506.1
    UniProtKB/Swiss-Prot
    B9A064
    UniProtKB/TrEMBL
    A0A0B4J231
    Related
    ENSP00000431254.1, ENST00000526893.6
    Conserved Domains (1) summary
    cd07699
    Location:115 → 207
    IgC_L; Immunoglobulin Constant domain

  2. NM_001256296.2 → NP_001243225.1  immunoglobulin lambda-like polypeptide 5 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the central coding region, and uses an alternate downstream start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AA847784, AC245028, AJ318022, AJ319669, AJ319670
    UniProtKB/TrEMBL
    Q6PJR7
    Conserved Domains (1) summary
    cd07699
    Location:40 → 132
    IgC_L; Immunoglobulin Constant domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    22887816..22896111
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    23310731..23319020
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B9A064.2 GenPept UniProtKB/Swiss-Prot:B9A064

Gene LinkOut

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