MIR2909 microRNA 2909 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MIR2909provided by HGNC
Official Full Name: microRNA 2909provided by HGNC
Primary source: HGNC:HGNC:38372
See related: Ensembl:ENSG00000276326 miRBase:MI0013083; AllianceGenome:HGNC:38372
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

Location:: 17q12

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (37033745..37033813)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (38020700..38020768)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (35391042..35391110)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Integrative Expression, Survival Analysis and Cellular miR-2909 Molecular Interplay in MRN Complex Check Point Sensor Genes (MRN-CSG) Involved in Breast Cancer.
Title: Integrative Expression, Survival Analysis and Cellular miR-2909 Molecular Interplay in MRN Complex Check Point Sensor Genes (MRN-CSG) Involved in Breast Cancer.
Prediction of recurrence of non-muscle invasive bladder cancer: The role of androgen receptor and miRNA-2909.
Title: Prediction of recurrence of non-muscle invasive bladder cancer: The role of androgen receptor and miRNA-2909.
Chemical induced pathognomonic features observed in human vitiligo are mediated through miR-2909 RNomics pathway.
Title: Chemical induced pathognomonic features observed in human vitiligo are mediated through miR-2909 RNomics pathway.
the role of miR-2909 in the regulation of mitochondrial function within human melanocytes, is reported.
Title: Mitochondrial respiration is restricted by miR-2909 within human melanocytes.
Studied recruitment patterns of urinary-exosomal miR-2909 in bladder and prostate cancer and its relation to disease severity.
Title: Urinary-exosomal miR-2909: A novel pathognomonic trait of prostate cancer severity.
Post-transcriptional modification, especially 3'-end adenylation and uridylation of miR-2909, exerts opposing effects that may contribute to direct its sorting into exosomes secreted by cancer cells.
Title: Cancer cells govern miR-2909 exosomal recruitment through its 3'-end post-transcriptional modification.
miR-2909 could play a vital role in prostate carcinogenesis through modulation of ISGylation system and TGFbeta signalling via STAT1/SOCS3.
Title: miR-2909 regulates ISGylation system via STAT1 signalling through negative regulation of SOCS3 in prostate cancer.
study shows that androgen receptor and miR-2909 drives the down-regulation of TGFBR2 by acting through positive feedback loop and thereby attenuating the inhibitory effects of TGFbeta signaling
Title: An androgen-regulated miR-2909 modulates TGFβ signalling through AR/miR-2909 axis in prostate cancer.
High miR-2909 expression is associated with Th1 immune response coupled with effector IgA class switching thereby tailoring their immune system to ensure increased risk to infections and chronic diseases.
Title: Arsenic toxi-RNomics has the ability to tailor the host immune response.
In the face of high glucose threat, mitochondrial UCP2 gene expression is regulated by miR-2909 and AATF.
Title: Mitochondrial uncoupling protein (UCP2) gene expression is regulated by miR-2909.

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Phenotypes

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Variation

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General gene information

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NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.