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CD74 CD74 molecule [ Callithrix jacchus (white-tufted-ear marmoset) ]

Gene ID: 100407145, updated on 8-Mar-2024

Summary

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Gene symbol
CD74
Gene description
CD74 molecule
See related
Ensembl:ENSCJAG00000020985
Gene type
protein coding
RefSeq status
MODEL
Organism
Callithrix jacchus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix
Orthologs
human mouse all
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Genomic context

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See CD74 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_03 current mCalJa1.2.pat.X (GCF_011100555.1) 2 NC_071443.1 (47180959..47192544, complement)
105 previous assembly Callithrix_jacchus_cj1700_1.1 (GCF_009663435.1) 2 NC_048384.1 (47452462..47464051, complement)

Chromosome 2 - NC_071443.1Genomic Context describing neighboring genes Neighboring gene arylsulfatase family member I Neighboring gene treacle ribosome biogenesis factor 1 Neighboring gene small nucleolar RNA SNORA8 Neighboring gene NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. De novo assembly of the common marmoset transcriptome from NextGen mRNA sequences. Maudhoo MD, et al. Gigascience, 2014. PMID 25243066, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables MHC class II protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cytokine receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables macrophage migration inhibitory factor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in T cell activation involved in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in antigen processing and presentation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of macrophage cytokine production IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of type 2 immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein trimerization IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
HLA class II histocompatibility antigen gamma chain
Names
CD74 molecule, major histocompatibility complex, class II invariant chain

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_011100555.1-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mCalJa1.2.pat.X

Genomic

  1. NC_071443.1 Reference mCalJa1.2.pat.X

    Range
    47180959..47192544 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008987870.4 → XP_008986118.1  HLA class II histocompatibility antigen gamma chain isoform X4

    Conserved Domains (2) summary
    pfam08831
    Location:120 → 188
    MHCassoc_trimer; Class II MHC-associated invariant chain trimerization domain
    pfam09307
    Location:1 → 112
    MHC2-interact; CLIP, MHC2 interacting

  2. XM_008987860.4 → XP_008986108.1  HLA class II histocompatibility antigen gamma chain isoform X3

    Related
    ENSCJAP00000039061.2
    Conserved Domains (2) summary
    pfam08831
    Location:120 → 188
    MHCassoc_trimer; Class II MHC-associated invariant chain trimerization domain
    pfam09307
    Location:1 → 112
    MHC2-interact; CLIP, MHC2 interacting

  3. XM_008987852.2 → XP_008986100.1  HLA class II histocompatibility antigen gamma chain isoform X2

    UniProtKB/TrEMBL
    A0A5F4VY01
    Related
    ENSCJAP00000042557.1
    Conserved Domains (3) summary
    cd00191
    Location:196 → 255
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    pfam08831
    Location:120 → 188
    MHCassoc_trimer; Class II MHC-associated invariant chain trimerization domain
    pfam09307
    Location:1 → 112
    MHC2-interact; CLIP, MHC2 interacting

  4. XM_035288543.2 → XP_035144434.1  HLA class II histocompatibility antigen gamma chain isoform X1

    UniProtKB/TrEMBL
    A0A2R8MZU6, A0A5F4VY01
    Conserved Domains (3) summary
    cd00191
    Location:196 → 255
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    pfam08831
    Location:120 → 188
    MHCassoc_trimer; Class II MHC-associated invariant chain trimerisation domain
    pfam09307
    Location:1 → 113
    MHC2-interact; CLIP, MHC2 interacting
Nucleotide Protein
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