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INSR insulin receptor [ Callithrix jacchus (white-tufted-ear marmoset) ]

Gene ID: 100403400, updated on 10-Oct-2024

Summary

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Gene symbol
INSR
Gene description
insulin receptor
Gene type
protein coding
RefSeq status
MODEL
Organism
Callithrix jacchus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix
Orthologs
human mouse all
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Genomic context

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See INSR in Genome Data Viewer
Location:
chromosome: 22
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2023_03 current mCalJa1.2.pat.X (GCF_011100555.1) 22 NC_071463.1 (6348813..6508930, complement)
105 previous assembly Callithrix_jacchus_cj1700_1.1 (GCF_009663435.1) 22 NC_048404.1 (6445953..6606578, complement)

Chromosome 22 - NC_071463.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100401969 Neighboring gene uncharacterized LOC128930569 Neighboring gene paired amphipathic helix protein Sin3b-like Neighboring gene uncharacterized LOC103789737 Neighboring gene Rho/Rac guanine nucleotide exchange factor 18 Neighboring gene peroxisomal biogenesis factor 11 gamma

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. De novo assembly of the common marmoset transcriptome from NextGen mRNA sequences. Maudhoo MD, et al. Gigascience, 2014. PMID 25243066, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables insulin receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables insulin receptor substrate binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol 3-kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of insulin receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
insulin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_011100555.1-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mCalJa1.2.pat.X

Genomic

  1. NC_071463.1 Reference mCalJa1.2.pat.X

    Range
    6348813..6508930 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_035286302.2 → XP_035142193.1  insulin receptor isoform X6

    UniProtKB/TrEMBL
    U3EYD1
    Conserved Domains (5) summary
    cd05061
    Location:1003 → 1290
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:855 → 932
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:179 → 337
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:359 → 470
    Recep_L_domain; Receptor L domain
    pfam17870
    Location:928 → 974
    Insulin_TMD; Insulin receptor trans-membrane segment

  2. XM_035286301.2 → XP_035142192.1  insulin receptor isoform X5

    UniProtKB/TrEMBL
    F7HRJ2, U3CV09, U3EYD1
    Conserved Domains (5) summary
    cd05061
    Location:1004 → 1291
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:855 → 932
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:179 → 337
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:359 → 470
    Recep_L_domain; Receptor L domain
    pfam17870
    Location:928 → 975
    Insulin_TMD; Insulin receptor trans-membrane segment

  3. XM_035286299.2 → XP_035142190.1  insulin receptor isoform X4

    UniProtKB/TrEMBL
    U3FCC1, U3FWA3
    Conserved Domains (5) summary
    cd05061
    Location:1016 → 1303
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:867 → 944
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:179 → 337
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:359 → 470
    Recep_L_domain; Receptor L domain
    pfam17870
    Location:940 → 987
    Insulin_TMD; Insulin receptor trans-membrane segment

  4. XM_054250108.1 → XP_054106083.1  insulin receptor isoform X3

  5. XM_054250107.1 → XP_054106082.1  insulin receptor isoform X2

  6. XM_054250106.1 → XP_054106081.1  insulin receptor isoform X1

  7. XM_054250109.1 → XP_054106084.1  insulin receptor isoform X8

  8. XM_035286305.2 → XP_035142196.2  insulin receptor isoform X7

Nucleotide Protein
Heading Accession and Version

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