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ugt1a4 UDP glucuronosyltransferase 1 family, polypeptide A4 [ Danio rerio (zebrafish) ]

Gene ID: 100384901, updated on 2-Nov-2024

Summary

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Official Symbol
ugt1a4provided by ZNC
Official Full Name
UDP glucuronosyltransferase 1 family, polypeptide A4provided by ZNC
Primary source
ZFIN:ZDB-GENE-080227-3
See related
Ensembl:ENSDARG00000006220 AllianceGenome:ZFIN:ZDB-GENE-080227-3
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Enables glucuronosyltransferase activity. Predicted to be located in endoplasmic reticulum membrane. Is expressed in gill; intestine; liver; spleen; and testis. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ugt1a4 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (9969987..9989687, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (9998614..10018314, complement)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene transcription termination factor, RNA polymerase II Neighboring gene protein arginine methyltransferase 2 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A1 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A2 Neighboring gene UDP glucuronosyltransferase 1 family a, b Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A5 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A6 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A7 Neighboring gene neurexophilin 2a Neighboring gene speckle type BTB/POZ protein like a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Adaptive evolution of multiple-variable exons and structural diversity of drug-metabolizing enzymes. Li C, et al. BMC Evol Biol, 2007 May 2. PMID 17475008, Free PMC Article
  2. Characterization of the zebrafish Ugt repertoire reveals a new class of drug-metabolizing UDP glucuronosyltransferases. Wang Y, et al. Mol Pharmacol, 2014 Jul. PMID 24728488
  3. Cloning and comparative analyses of the zebrafish Ugt repertoire reveal its evolutionary diversity. Huang H, et al. PLoS One, 2010 Feb 10. PMID 20161780, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Clone Names

  • MGC112502, MGC192482

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables UDP-glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glucuronosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glucuronosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
UDP-glucuronosyltransferase 1-4
NP_001170815.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177344.2 → NP_001170815.2  UDP-glucuronosyltransferase 1-4 precursor

    See identical proteins and their annotated locations for NP_001170815.2

    Status: VALIDATED

    Source sequence(s)
    AL954329, BC165394
    UniProtKB/TrEMBL
    B5DDQ4, F6P4L0, Q561S7
    Related
    ENSDARP00000075904.4, ENSDART00000081463.6
    Conserved Domains (2) summary
    PHA03392
    Location:229 → 497
    egt; ecdysteroid UDP-glucosyltransferase; Provisional
    pfam00201
    Location:19 → 508
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    9969987..9989687 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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