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arhgap5.S Rho GTPase activating protein 5 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 100381143, updated on 18-Sep-2024

Summary

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Official Symbol
arhgap5.S
Official Full Name
Rho GTPase activating protein 5 S homeolog
Primary source
Xenbase:XB-GENE-982384
Locus tag
XELAEV_18042626mg
See related
EnsemblRapid:ENSXLAG00005006460
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
gfi2; p190-b; arhgap5; rhogap5; p190brhogap
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Genomic context

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See arhgap5.S in Genome Data Viewer
Location:
chromosome: 8S
Exon count:
10
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 8S NC_054386.1 (87590967..87634367)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 8S NC_030739.1 (85220135..85263605)

Chromosome 8S - NC_054386.1Genomic Context describing neighboring genes Neighboring gene synaptonemal complex central element protein 1 Neighboring gene uncharacterized LOC108700307 Neighboring gene uncharacterized LOC108700312 Neighboring gene A-kinase anchor protein 6 Neighboring gene neuronal PAS domain protein 3 S homeolog Neighboring gene uncharacterized LOC108700314

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Xenopus Kazrin interacts with ARVCF-catenin, spectrin and p190B RhoGAP, and modulates RhoA activity and epithelial integrity. Cho K, et al. J Cell Sci, 2010 Dec 1. PMID 21062899, Free PMC Article
  2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kazrin interacts with ARVCF-catenin, spectrin and p190B RhoGAP, and modulates RhoA activity.
    Title: Xenopus Kazrin interacts with ARVCF-catenin, spectrin and p190B RhoGAP, and modulates RhoA activity and epithelial integrity.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cell size IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Rho GTPase activating protein 5; rho GTPase activating protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001174033.1 → NP_001167504.1  Rho GTPase activating protein 5 isoform 2

    See identical proteins and their annotated locations for NP_001167504.1

    Status: PROVISIONAL

    Source sequence(s)
    BC133756
    UniProtKB/TrEMBL
    A3KNC3
    Conserved Domains (1) summary
    cl02570
    Location:1 → 122
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

  2. NM_001375358.1 → NP_001362287.1  Rho GTPase activating protein 5 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAGEVR010000037
    UniProtKB/TrEMBL
    A0A1L8F459, A0A974C4C2, Q5XGX8
    Related
    ENSXLAP00005019245.1, ENSXLAT00005019580.1
    Conserved Domains (4) summary
    smart00441
    Location:430 → 482
    FF; Contains two conserved F residues
    cd04373
    Location:1254 → 1438
    RhoGAP_p190; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an ...
    pfam16512
    Location:260 → 339
    RhoGAP-FF1; p190-A and -B Rho GAPs FF domain
    cl38936
    Location:28 → 244
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054386.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    87590967..87634367
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041574047.1 → XP_041429981.1  rho GTPase activating protein 5 isoform X1

    UniProtKB/TrEMBL
    A0A8J1LMM6, Q5XGX8
    Conserved Domains (3) summary
    smart00441
    Location:430 → 482
    FF; Contains two conserved F residues
    cd04373
    Location:1254 → 1440
    RhoGAP_p190; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an ...
    cl38936
    Location:28 → 244
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. XM_041574046.1 → XP_041429980.1  rho GTPase activating protein 5 isoform X1

    UniProtKB/TrEMBL
    A0A8J1LMM6, Q5XGX8
    Related
    ENSXLAP00005019254.1, ENSXLAT00005019589.1
    Conserved Domains (3) summary
    smart00441
    Location:430 → 482
    FF; Contains two conserved F residues
    cd04373
    Location:1254 → 1440
    RhoGAP_p190; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an ...
    cl38936
    Location:28 → 244
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. XM_041574048.1 → XP_041429982.1  rho GTPase activating protein 5 isoform X2

    UniProtKB/TrEMBL
    A0A8J1LKD1, Q5XGX8
    Conserved Domains (2) summary
    smart00441
    Location:430 → 482
    FF; Contains two conserved F residues
    cl38936
    Location:28 → 244
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version

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