tcap.S titin-cap S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: tcap.S
Official Full Name: titin-cap S homeolog
Primary source: Xenbase:XB-GENE-1013769
Locus tag: XELAEV_18045928mg
See related: EnsemblRapid:ENSXLAG00005029002 AllianceGenome:Xenbase:XB-GENE-1013769
Gene type: protein coding
RefSeq status: MODEL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: tcap; telethonin
Summary: Predicted to enable protein-macromolecule adaptor activity; titin Z domain binding activity; and titin binding activity. Predicted to be a structural constituent of muscle. Predicted to act upstream of or within several processes, including detection of muscle stretch; myofibril assembly; and striated muscle contraction. Predicted to be located in Z disc. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2G and hypertrophic cardiomyopathy 25. Orthologous to human TCAP (titin-cap). [provided by Alliance of Genome Resources, Nov 2024]
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Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	9_10S	NC_054388.1 (2006468..2008507, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	9_10S	NC_030741.1 (1923196..1925405, complement)

Chromosome 9_10S - NC_054388.1 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Distinct roles for telethonin N-versus C-terminus in sarcomere assembly and maintenance.
Title: Distinct roles for telethonin N-versus C-terminus in sarcomere assembly and maintenance.

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables protein-macromolecule adaptor activity	IEA Inferred from Electronic Annotation more info
enables structural constituent of muscle	IEA Inferred from Electronic Annotation more info
enables titin Z domain binding	IEA Inferred from Electronic Annotation more info
enables titin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cardiac muscle contraction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cardiac muscle tissue morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cardiac myofibril assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within detection of muscle stretch	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sarcomerogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skeletal muscle contraction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skeletal muscle myosin thick filament assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skeletal muscle thin filament assembly	IEA Inferred from Electronic Annotation more info