ncbp2.L nuclear cap binding protein subunit 2 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: ncbp2.L
Official Full Name: nuclear cap binding protein subunit 2 L homeolog
Primary source: Xenbase:XB-GENE-1005792
Locus tag: XELAEV_18027510mg
See related: EnsemblRapid:ENSXLAG00005017134 AllianceGenome:Xenbase:XB-GENE-1005792
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: cbp20; ncbp2; CBP20-X
Summary: Predicted to enable RNA 7-methylguanosine cap binding activity; mRNA binding activity; and snRNA binding activity. Acts upstream of or within several processes, including RNA splicing; positive regulation of RNA export from nucleus; and snRNA export from nucleus. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of nuclear cap binding activity complex. Orthologous to human NCBP2 (nuclear cap binding protein subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 5L

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	5L	NC_054379.1 (112898983..112903165, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	5L	NC_030732.1 (102203917..102208099, complement)

Chromosome 5L - NC_054379.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study of 14 individual homologs of human 3q29 genes and 314 pairwise interactions for developmental phenotypes in D. melanogaster and X. laevis models found that homologs of NCBP2 in Drosophila (Cbp20) and X. laevis (ncbp2) acts as a key modifier genes within the region, enhancing the developmental phenotypes of each of the homologs for other 3q29 genes and leading to disruptions in apoptosis and cell cycle pathways.
Title: NCBP2 modulates neurodevelopmental defects of the 3q29 deletion in Drosophila and Xenopus laevis models.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables RNA 7-methylguanosine cap binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
NOT enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA cap binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables snRNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA splicing	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within RNA splicing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within eye development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mRNA cis splicing, via spliceosome	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA cis splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of RNA export from nucleus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of translation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of translational initiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulatory ncRNA-mediated gene silencing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within snRNA export from nucleus	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
part_of nuclear cap binding complex	IEA Inferred from Electronic Annotation more info
part_of nuclear cap binding complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: nuclear cap-binding protein subunit 2

Names: 20 kDa nuclear cap-binding protein; CAP binding protein; NCBP 20 kDa subunit; nuclear cap binding protein subunit 2, 20kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001174005.1 → NP_001167476.1 nuclear cap-binding protein subunit 2

See identical proteins and their annotated locations for NP_001167476.1

Status: PROVISIONAL

Source sequence(s)

BC072902

UniProtKB/Swiss-Prot

P52299, Q6GQ46

UniProtKB/TrEMBL

A0A974CY90

Related

ENSXLAP00005050561.1, ENSXLAT00005051702.1

Conserved Domains (2) summary

COG0724
Location:34 → 137

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12240
Location:39 → 116

RRM_NCBP2; RNA recognition motif found in nuclear cap-binding protein subunit 2 (CBP20) and similar proteins

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054379.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

112898983..112903165 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)