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Fam170b family with sequence similarity 170, member B [ Rattus norvegicus (Norway rat) ]

Gene ID: 100362169, updated on 2-Nov-2024

Summary

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Official Symbol
Fam170bprovided by RGD
Official Full Name
family with sequence similarity 170, member Bprovided by RGD
Primary source
RGD:2318714
See related
EnsemblRapid:ENSRNOG00000020077 AllianceGenome:RGD:2318714
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in fertilization; positive regulation of acrosome reaction; and regulation of fertilization. Predicted to be located in outer acrosomal membrane. Predicted to be active in acrosomal vesicle. Orthologous to human FAM170B (family with sequence similarity 170 member B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 117.0) See more
Orthologs
human mouse all
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Genomic context

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See Fam170b in Genome Data Viewer
Location:
16p16
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (8108210..8111020)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (8101914..8104724)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (9074044..9076885)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 10 open reading frame 71 Neighboring gene uncharacterized LOC102547142 Neighboring gene uncharacterized LOC134482315 Neighboring gene transmembrane protein 273 Neighboring gene V-set and transmembrane domain containing 4 Neighboring gene WDFY family member 4 Neighboring gene leucine rich repeat containing 18

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. FAM170B, a novel acrosomal protein involved in fertilization in mice. Li Y, et al. Mol Reprod Dev, 2015 Oct. PMID 26179146
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in fertilization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of acrosome reaction ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of fertilization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in acrosomal vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in acrosomal vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in outer acrosomal membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein FAM170B
Names
rCG42349-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399444.1 → NP_001386373.1  protein FAM170B

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A0A6B9RX81, D3ZLX4
    Related
    ENSRNOP00000027193.8, ENSRNOT00000027193.9
    Conserved Domains (1) summary
    pfam17734
    Location:195 → 240
    Spt46; Spermatogenesis-associated protein 46

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    8108210..8111020
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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