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Rasgef1b RasGEF domain family, member 1B [ Rattus norvegicus (Norway rat) ]

Gene ID: 100361238, updated on 2-Nov-2024

Summary

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Official Symbol
Rasgef1bprovided by RGD
Official Full Name
RasGEF domain family, member 1Bprovided by RGD
Primary source
RGD:1562220
See related
EnsemblRapid:ENSRNOG00000002345 AllianceGenome:RGD:1562220
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1562220
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction. Predicted to be active in plasma membrane. Orthologous to human RASGEF1B (RasGEF domain family member 1B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 130.1), Kidney (RPKM 109.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rasgef1b in Genome Data Viewer
Location:
14p22
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (10164366..10684184)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (9859512..10380044)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (11499692..12028513)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096568 Neighboring gene uncharacterized LOC134481713 Neighboring gene uncharacterized LOC108352713 Neighboring gene uncharacterized LOC134481715 Neighboring gene eukaryotic translation elongation factor 2, pseudogene 3 Neighboring gene uncharacterized LOC134481714 Neighboring gene uncharacterized LOC120096569 Neighboring gene uncharacterized LOC120096570 Neighboring gene PRELI domain containing 1, pseudogene 4 Neighboring gene uncharacterized LOC134481716 Neighboring gene protein kinase cGMP-dependent 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. RasGEF1A and RasGEF1B are guanine nucleotide exchange factors that discriminate between Rap GTP-binding proteins and mediate Rap2-specific nucleotide exchange. Yaman E, et al. FEBS J, 2009 Aug. PMID 19645719
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RasGEF domain family, member 1B; ras-GEF domain-containing family member 1B
Names
GPIgamma4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001432998.1 → NP_001419927.1  RasGEF domain family, member 1B isoform 1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000014

  2. NM_001433246.1 → NP_001420175.1  RasGEF domain family, member 1B isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    D3ZJN7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    10164366..10684184
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017599428.3 → XP_017454917.1  ras-GEF domain-containing family member 1B isoform X2

  2. XM_017599427.3 → XP_017454916.1  ras-GEF domain-containing family member 1B isoform X1

    UniProtKB/TrEMBL
    A0A8I6AKE8

  3. XM_017599429.3 → XP_017454918.1  ras-GEF domain-containing family member 1B isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZKP1
    Related
    ENSRNOP00000093715.2, ENSRNOT00000115895.2

  4. XM_063273740.1 → XP_063129810.1  ras-GEF domain-containing family member 1B isoform X4

    Related
    ENSRNOP00000078329.1, ENSRNOT00000115253.2

  5. XM_002728083.7 → XP_002728129.2  ras-GEF domain-containing family member 1B isoform X5

    Related
    ENSRNOP00000003207.8, ENSRNOT00000003207.8
    Conserved Domains (2) summary
    cd06224
    Location:42 → 167
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00147
    Location:205 → 454
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
Nucleotide Protein Strain
Heading Accession and Version

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