Ppial4d peptidylprolyl isomerase A (cyclophilin A)-like 4D [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Ppial4dprovided by RGD
Full Name: peptidylprolyl isomerase A (cyclophilin A)-like 4Dprovided by RGD
Primary source: RGD:2321083
See related: AllianceGenome:RGD:2321083
Gene type: protein coding
RefSeq status: MODEL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable heparan sulfate binding activity; integrin binding activity; and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in several processes, including cell adhesion molecule production; regulation of intracellular signal transduction; and regulation of protein modification process. Predicted to be located in cytosol; extracellular region; and nucleus. Human ortholog(s) of this gene implicated in cholangiocarcinoma and human immunodeficiency virus infectious disease. Orthologous to human PPIA (peptidylprolyl isomerase A). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

Location:: 14p21

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (21361379..21362147)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (21006522..21007284)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (22706906..22707648)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

RH125522 (e-PCR)
- UniSTS:162338

Ppia (e-PCR), detects polymorphism
- UniSTS:531290

Ppia (e-PCR), detects polymorphism
- UniSTS:531291

Ppia (e-PCR), detects polymorphism
- UniSTS:186228

Ppi-rs (e-PCR), detects polymorphism
- UniSTS:144251

PMC262691P6 (e-PCR)
- UniSTS:272328

UniSTS:265677 (e-PCR)
- UniSTS:265677

Ppia (e-PCR), detects polymorphism
- UniSTS:265677

Homology

Orthologs from OrthoDB

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables heparan sulfate binding	ISS Inferred from Sequence or Structural Similarity more info
enables integrin binding	ISS Inferred from Sequence or Structural Similarity more info
enables peptidyl-prolyl cis-trans isomerase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in activation of protein kinase B activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell adhesion molecule production	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to oxidative stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in endothelial cell activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in leukocyte chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein K48-linked ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of stress-activated MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in neutrophil chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in platelet activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in platelet aggregation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein peptidyl-prolyl isomerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of apoptotic signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of viral genome replication	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: peptidyl-prolyl cis-trans isomerase A

Names: TRIMCyp-like

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

21361379..21362147

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006250801.5 → XP_006250863.1 peptidyl-prolyl cis-trans isomerase A

See identical proteins and their annotated locations for XP_006250863.1

UniProtKB/Swiss-Prot

P10111, P18303, Q5BK98

UniProtKB/TrEMBL

A6IKT9, A6IKU0

Conserved Domains (1) summary

cd01926
Location:4 → 162

cyclophilin_ABH_like; Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which accelerates protein folding ...