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Taf3 TATA-box binding protein associated factor 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100360100, updated on 18-Sep-2024

Summary

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Official Symbol
Taf3provided by RGD
Official Full Name
TATA-box binding protein associated factor 3provided by RGD
Primary source
RGD:2324594
See related
AllianceGenome:RGD:2324594
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable p53 binding activity and transcription regulator inhibitor activity. Predicted to be involved in maintenance of protein location in nucleus; negative regulation of DNA-binding transcription factor activity; and negative regulation of transcription by RNA polymerase II. Predicted to be located in nuclear membrane and nucleoplasm. Predicted to be part of transcription factor TFIID complex. Orthologous to human TAF3 (TATA-box binding protein associated factor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 34.1), Kidney (RPKM 30.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Taf3 in Genome Data Viewer
Location:
17q12.3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (73365162..73518053)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (68455389..68608367)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (72240785..72393448)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC102546431 Neighboring gene ATP synthase F1 subunit gamma Neighboring gene Kin17 DNA and RNA binding protein Neighboring gene uncharacterized LOC120097843 Neighboring gene GATA binding protein 3 Neighboring gene uncharacterized LOC134482600

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function. Bereczki O, et al. BMC Mol Biol, 2008 Jun 12. PMID 18549481, Free PMC Article
  2. The nuclear import of TAF10 is regulated by one of its three histone fold domain-containing interaction partners. Soutoglou E, et al. Mol Cell Biol, 2005 May. PMID 15870280, Free PMC Article
  3. Structural bioinformatics of the general transcription factor TFIID. Malkowska M, et al. Biochimie, 2013 Apr. PMID 23146842
  4. The TFIID components human TAF(II)140 and Drosophila BIP2 (TAF(II)155) are novel metazoan homologues of yeast TAF(II)47 containing a histone fold and a PHD finger. Gangloff YG, et al. Mol Cell Biol, 2001 Aug. PMID 11438666, Free PMC Article
  5. The intracellular localisation of TAF7L, a paralogue of transcription factor TFIID subunit TAF7, is developmentally regulated during male germ-cell differentiation. Pointud JC, et al. J Cell Sci, 2003 May 1. PMID 12665565

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables p53 binding ISO
Inferred from Sequence Orthology
more info
  
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables proton-transporting ATP synthase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
  
enables transcription regulator inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in mRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in maintenance of protein location in nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription initiation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in proton motive force-driven ATP synthesis IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in male germ cell nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of proton-transporting ATP synthase complex, catalytic core F(1) IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIID complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transcription initiation factor TFIID subunit 3
Names
TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271342.1 → NP_001258271.1  transcription initiation factor TFIID subunit 3

    See identical proteins and their annotated locations for NP_001258271.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    A6JLU9, D3ZPB7
    Conserved Domains (3) summary
    smart00576
    Location:5 → 79
    BTP; Bromodomain transcription factors and PHD domain containing proteins
    cd15522
    Location:867 → 912
    PHD_TAF3; PHD finger found in transcription initiation factor TFIID subunit 3 (TAF3)
    pfam16294
    Location:596 → 654
    RSB_motif; RNSP1-SAP18 binding (RSB) motif

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    73365162..73518053
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006254228.5 → XP_006254290.1  transcription initiation factor TFIID subunit 3 isoform X1

    See identical proteins and their annotated locations for XP_006254290.1

    UniProtKB/TrEMBL
    A6JLU9, D3ZPB7
    Conserved Domains (3) summary
    smart00576
    Location:5 → 79
    BTP; Bromodomain transcription factors and PHD domain containing proteins
    cd15522
    Location:867 → 912
    PHD_TAF3; PHD finger found in transcription initiation factor TFIID subunit 3 (TAF3)
    pfam16294
    Location:596 → 654
    RSB_motif; RNSP1-SAP18 binding (RSB) motif
Nucleotide Protein Strain
Heading Accession and Version

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