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LOC100352996 immunoglobulin heavy variable 3-66 [ Oryctolagus cuniculus (rabbit) ]

Gene ID: 100352996, updated on 9-Nov-2023

Summary

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Gene symbol
LOC100352996
Gene description
immunoglobulin heavy variable 3-66
Gene type
protein coding
RefSeq status
MODEL
Organism
Oryctolagus cuniculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Also known as
VH; IgH; IGHM; IGHVDJ
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Genomic context

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See LOC100352996 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) Unplaced Scaffold NW_026259486.1 (238750..253133, complement)

NW_026259486.1Genomic Context describing neighboring genes Neighboring gene immunoglobulin heavy variable 3-66-like Neighboring gene immunoglobulin heavy variable 3-74-like Neighboring gene immunoglobulin heavy variable 3-23-like Neighboring gene immunoglobulin heavy variable 3-11 Neighboring gene Ig heavy chain V-A1 region BS-5-like Neighboring gene immunoglobulin heavy variable 3-23-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_026259486 Unplaced Scaffold Reference UM_NZW_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Intestinal microflora and diversification of the rabbit antibody repertoire. Lanning D, et al. J Immunol, 2000 Aug 15. PMID 10925284
  2. VH mutant rabbits lacking the VH1a2 gene develop a2+ B cells in the appendix by gene conversion-like alteration of a rearranged VH4 gene. Sehgal D, et al. J Immunol, 1998 Feb 1. PMID 9570541
  3. VDJ genes in VHa2 allotype-suppressed rabbits. Limited germline VH gene usage and accumulation of somatic mutations in D regions. Short JA, et al. J Immunol, 1991 Dec 1. PMID 1940383
  4. VH gene expression and regulation in the mutant Alicia rabbit. Rescue of VHa2 allotype expression. Chen HT, et al. J Immunol, 1993 Apr 1. PMID 8454855
  5. Positive selection of the peripheral B cell repertoire in gut-associated lymphoid tissues. Rhee KJ, et al. J Exp Med, 2005 Jan 3. PMID 15623575, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables antigen binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables immunoglobulin receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in B cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in complement activation, classical pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in defense response to bacterium IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phagocytosis, engulfment IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phagocytosis, recognition IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of B cell activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in blood microparticle IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of immunoglobulin complex, circulating IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
immunoglobulin heavy variable 3-66
Names
Ig heavy chain V-III region VH26
IgM heavy chain VDJ region
immunglobulin heavy chain variable region
immunoglobulin heavy chain V-D-J region
immunoglobulin heavy chain V-region
immunoglobulin heavy chain VDJ region
immunoglobulin heavy chain variable region
immunoglobulin mu heavy chain VDJ region

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UM_NZW_1.0 Primary Assembly

Genomic

  1. NW_026259486.1 Reference UM_NZW_1.0 Primary Assembly

    Range
    238750..253133 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_051840258.1 → XP_051696218.1  immunoglobulin heavy variable 3-66

Nucleotide Protein
Heading Accession and Version

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