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LRP2 LDL receptor related protein 2 [ Oryctolagus cuniculus (rabbit) ]

Gene ID: 100346275, updated on 8-Mar-2024

Summary

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Gene symbol
LRP2
Gene description
LDL receptor related protein 2
Gene type
protein coding
RefSeq status
MODEL
Organism
Oryctolagus cuniculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Orthologs
human mouse all
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Genomic context

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See LRP2 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
83
Annotation release Status Assembly Chr Location
RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) 7 NC_067380.1 (64378451..64671167)

Chromosome 7 - NC_067380.1Genomic Context describing neighboring genes Neighboring gene kelch like family member 41 Neighboring gene Bardet-Biedl syndrome 5 Neighboring gene ribosomal biogenesis factor-like Neighboring gene uncharacterized LOC103348770 Neighboring gene ATP synthase subunit g, mitochondrial-like Neighboring gene dehydrogenase/reductase 9

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_067380.1 Chromosome 7 Reference UM_NZW_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Megalin mediates transepithelial albumin clearance from the alveolar space of intact rabbit lungs. Buchäckert Y, et al. J Physiol, 2012 Oct 15. PMID 22826129, Free PMC Article
  2. Megalin is downregulated via LPS-TNF-α-ERK1/2 signaling pathway in proximal tubule cells. Takeyama A, et al. Biochem Biophys Res Commun, 2011 Apr 1. PMID 21371423
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Megalin mediates transepithelial albumin clearance from the alveolar space of intact rabbit lungs
    Title: Megalin mediates transepithelial albumin clearance from the alveolar space of intact rabbit lungs.
  2. low-level LPS-mediated TNF-alpha-ERK1/2 signaling pathway is involved in downregulation of megalin expression in IRPTCs.
    Title: Megalin is downregulated via LPS-TNF-α-ERK1/2 signaling pathway in proximal tubule cells.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
low-density lipoprotein receptor-related protein 2
Names
low density lipoprotein receptor-related protein 2
low density lipoprotein-related protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UM_NZW_1.0 Primary Assembly

Genomic

  1. NC_067380.1 Reference UM_NZW_1.0 Primary Assembly

    Range
    64378451..64671167
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_051849416.1 → XP_051705376.1  low-density lipoprotein receptor-related protein 2 isoform X4

  2. XM_051849415.1 → XP_051705375.1  low-density lipoprotein receptor-related protein 2 isoform X2

  3. XM_051849414.1 → XP_051705374.1  low-density lipoprotein receptor-related protein 2 isoform X1

  4. XM_008258707.3 → XP_008256929.1  low-density lipoprotein receptor-related protein 2 isoform X3

    Conserved Domains (11) summary
    smart00192
    Location:2908 → 2940
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:2545 → 2585
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:4006 → 4037
    EGF_CA; Calcium-binding EGF-like domain
    COG3391
    Location:2092 → 2288
    YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
    cd00112
    Location:1271 → 1305
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:2100 → 2142
    NHL; NHL repeat [structural motif]
    pfam00058
    Location:4196 → 4236
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam12662
    Location:3131 → 3154
    cEGF; Complement Clr-like EGF-like
    pfam14670
    Location:1353 → 1388
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:3146 → 3189
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    cl18310
    Location:2100 → 2293
    NHL; NHL repeat unit of beta-propeller proteins

  5. XM_051849418.1 → XP_051705378.1  low-density lipoprotein receptor-related protein 2 isoform X6

  6. XM_051849417.1 → XP_051705377.1  low-density lipoprotein receptor-related protein 2 isoform X5

  7. XM_051849419.1 → XP_051705379.1  low-density lipoprotein receptor-related protein 2 isoform X7

Nucleotide Protein
Heading Accession and Version

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