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ALOX12 arachidonate 12-lipoxygenase, 12S type [ Oryctolagus cuniculus (rabbit) ]

Gene ID: 100340525, updated on 8-Mar-2024

Summary

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Gene symbol
ALOX12
Gene description
arachidonate 12-lipoxygenase, 12S type
See related
Ensembl:ENSOCUG00000021659
Gene type
protein coding
RefSeq status
MODEL
Organism
Oryctolagus cuniculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Orthologs
human mouse all
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Genomic context

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See ALOX12 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) 19 NC_067392.1 (9650435..9665954, complement)

Chromosome 19 - NC_067392.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC127484443 Neighboring gene BPTF associated chromatin complex component 1 Neighboring gene ribonuclease K Neighboring gene uncharacterized LOC103351478 Neighboring gene U1 spliceosomal RNA Neighboring gene arachidonate 15-lipoxygenase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_067392.1 Chromosome 19 Reference UM_NZW_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables arachidonate 12(S)-lipoxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables arachidonate 15-lipoxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables linoleate 13S-lipoxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in linoleic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in lipid oxidation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in sarcolemma IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
polyunsaturated fatty acid lipoxygenase ALOX12

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UM_NZW_1.0 Primary Assembly

Genomic

  1. NC_067392.1 Reference UM_NZW_1.0 Primary Assembly

    Range
    9650435..9665954 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_002718820.4 → XP_002718866.1  polyunsaturated fatty acid lipoxygenase ALOX12

    UniProtKB/TrEMBL
    G1U492
    Related
    ENSOCUP00000024211.1
    Conserved Domains (2) summary
    cd01753
    Location:2 → 111
    PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
    pfam00305
    Location:219 → 654
    Lipoxygenase; Lipoxygenase

RNA

  1. XR_007911417.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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