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nck1b NCK adaptor protein 1b [ Danio rerio (zebrafish) ]

Gene ID: 100334953, updated on 2-Nov-2024

Summary

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Official Symbol
nck1bprovided by ZNC
Official Full Name
NCK adaptor protein 1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-090317-1
See related
Ensembl:ENSDARG00000075369 AllianceGenome:ZFIN:ZDB-GENE-090317-1
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable ephrin receptor binding activity; receptor tyrosine kinase binding activity; and signaling adaptor activity. Predicted to be involved in several processes, including ephrin receptor signaling pathway; positive regulation of translation in response to endoplasmic reticulum stress; and regulation of response to endoplasmic reticulum stress. Predicted to act upstream of or within regulation of translation. Predicted to be located in cytosol and endoplasmic reticulum. Predicted to be active in cytoplasm. Orthologous to human NCK1 (NCK adaptor protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See nck1b in Genome Data Viewer
Location:
chromosome: 24
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (3347514..3429442, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (3315727..3375740, complement)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene succinyl-CoA:glutarate-CoA transferase Neighboring gene glycogenin 1b Neighboring gene 3-hydroxybutyrate dehydrogenase, type 1 Neighboring gene solute carrier family 35 member G2b Neighboring gene isopentenyl-diphosphate delta isomerase 1 Neighboring gene WD repeat domain 37

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. CRK and NCK adaptors may functionally overlap in zebrafish neurodevelopment, as indicated by common binding partners and overlapping expression patterns. Stergas HR, et al. FEBS Lett, 2024 Feb. PMID 38058169
  2. Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Thyme SB, et al. Cell, 2019 Apr 4. PMID 30929901, Free PMC Article
  3. Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Giffen KP, et al. Front Neurosci, 2019. PMID 31680844, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ephrin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables receptor tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ephrin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of PERK-mediated unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of translation in response to endoplasmic reticulum stress IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SH2/SH3 adapter protein Nck1
Names
nck1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    3347514..3429442 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068217135.1 → XP_068073236.1  SH2/SH3 adapter protein Nck1 isoform X1

    Related
    ENSDARP00000153435.1, ENSDART00000184346.1

  2. XM_002666595.7 → XP_002666641.1  SH2/SH3 adapter protein Nck1 isoform X1

    See identical proteins and their annotated locations for XP_002666641.1

    UniProtKB/TrEMBL
    A0A8M1RRX6, E7F6M0
    Related
    ENSDARP00000121375.1, ENSDART00000132648.3
    Conserved Domains (4) summary
    cd11900
    Location:3 → 61
    SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
    cd11901
    Location:109 → 163
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:194 → 250
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein
    cl15255
    Location:282 → 378
    SH2; Src homology 2 (SH2) domain

  3. XM_005162524.4 → XP_005162581.1  SH2/SH3 adapter protein Nck1 isoform X2

    UniProtKB/TrEMBL
    A0A8M2B9E1
    Conserved Domains (3) summary
    cd11901
    Location:45 → 99
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:130 → 186
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein
    cl15255
    Location:218 → 314
    SH2; Src homology 2 (SH2) domain
Nucleotide Protein Strain
Heading Accession and Version

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