ambra1a autophagy/beclin-1 regulator 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ambra1aprovided by ZNC
Official Full Name: autophagy/beclin-1 regulator 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-111104-2
See related: Ensembl:ENSDARG00000008322 AllianceGenome:ZFIN:ZDB-GENE-111104-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ambra1
Summary: Acts upstream of or within several processes, including autophagy; locomotory behavior; and skeletal muscle fiber development. Is expressed in several structures, including blastodisc; oral cavity; otic vesicle; pleuroperitoneal region; and tail bud. Orthologous to human AMBRA1 (autophagy and beclin 1 regulator 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 7

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (39253519..39360325, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (38982259..39089386, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zebrafish ambra1b knockout reveals a novel role for Ambra1 in primordial germ cells survival, sex differentiation and reproduction.
Title: Zebrafish ambra1b knockout reveals a novel role for Ambra1 in primordial germ cells survival, sex differentiation and reproduction.
The role of ambra1 in Pb-induced developmental neurotoxicity in zebrafish.
Title: The role of ambra1 in Pb-induced developmental neurotoxicity in zebrafish.
ambra1a and ambra1b are required for the correct development and morphogenesis of skeletal muscle.
Title: Zebrafish ambra1a and ambra1b knockdown impairs skeletal muscle development.
Ambra1 knockdown causes severe embryonic malformations.
Title: Ambra1 knockdown in zebrafish leads to incomplete development due to severe defects in organogenesis.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ubiquitin-like ligase-substrate adaptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in autophagosome assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within autophagy	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chordate embryonic development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within chordate embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within locomotory behavior	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of free ubiquitin chain polymerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mitophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of regulatory T cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein polyubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of G1/S transition of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within skeletal muscle fiber development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within skeletal muscle fiber development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Cul4-RING E3 ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in autophagosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: activating molecule in BECN1-regulated autophagy protein 1A

Names: activating molecule in BECN1-regulated autophagy protein 1a; activating molecule in beclin-1-regulated autophagy; autophagy/beclin-1 regulator 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001281992.1 → NP_001268921.1 activating molecule in BECN1-regulated autophagy protein 1A

See identical proteins and their annotated locations for NP_001268921.1

Status: PROVISIONAL

Source sequence(s)

HE602022

UniProtKB/Swiss-Prot

A0A1D5NSZ3, E7FAG6, I3IRN2, L0N9D3, L0N9D4, L0N9K3

Related

ENSDARP00000088806.4, ENSDART00000098033.6

Conserved Domains (2) summary

sd00039
Location:58 → 91

7WD40; WD40 repeat [structural motif]

cl29593
Location:58 → 197

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007118.7 Reference GRCz11 Primary Assembly

Range

39253519..39360325 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_002667669.7 → XP_002667715.3 activating molecule in BECN1-regulated autophagy protein 1A isoform X1

UniProtKB/TrEMBL

A0A8M1RIC3

Conserved Domains (3) summary

COG2319
Location:43 → 197

WD40; WD40 repeat [General function prediction only]

sd00039
Location:58 → 91

7WD40; WD40 repeat [structural motif]

cl02567
Location:58 → 197

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...