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capn15 calpain 15 [ Danio rerio (zebrafish) ]

Gene ID: 100330198, updated on 2-Nov-2024

Summary

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Official Symbol
capn15provided by ZNC
Official Full Name
calpain 15provided by ZNC
Primary source
ZFIN:ZDB-GENE-140106-70
See related
Ensembl:ENSDARG00000060600 AllianceGenome:ZFIN:ZDB-GENE-140106-70
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
solh
Summary
Predicted to enable calcium-dependent cysteine-type endopeptidase activity and metal ion binding activity. Predicted to act upstream of or within proteolysis. Orthologous to human CAPN15 (calpain 15). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See capn15 in Genome Data Viewer
Location:
chromosome: 24
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (39027353..39084491)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (39139516..39197099)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene noggin 2 Neighboring gene ankyrin repeat and fibronectin type III domain containing 1b Neighboring gene uncharacterized LOC137489278 Neighboring gene putative protein MSS51 homolog, mitochondrial Neighboring gene MSS51 mitochondrial translational activator

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. KEPI plays a negative role in the repression that accompanies translational inhibition guided by the uORF element of human CHOP transcript during stress response. Lee HC, et al. Gene, 2022 Apr 5. PMID 35031423
  2. PTC-bearing mRNA elicits a genetic compensation response via Upf3a and COMPASS components. Ma Z, et al. Nature, 2019 Apr. PMID 30944473
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium-dependent cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
calpain-15
Names
small optic lobes homolog
zmp:0000001110

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    39027353..39084491
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_002663847.7 → XP_002663893.2  calpain-15 isoform X2

    UniProtKB/TrEMBL
    A0A8M1RRB5, E7FAX5
    Related
    ENSDARP00000080000.4, ENSDART00000085565.6
    Conserved Domains (4) summary
    smart00547
    Location:47 → 71
    ZnF_RBZ; Zinc finger domain
    sd00025
    Location:167 → 186
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    sd00029
    Location:384 → 403
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00648
    Location:526 → 829
    Peptidase_C2; Calpain family cysteine protease

  2. XM_021470406.2 → XP_021326081.1  calpain-15 isoform X1

    UniProtKB/TrEMBL
    A0A2R8Q9Z9, A0A8M2BLF5
    Related
    ENSDARP00000151290.1, ENSDART00000185763.1
    Conserved Domains (4) summary
    smart00547
    Location:78 → 102
    ZnF_RBZ; Zinc finger domain
    cd00044
    Location:545 → 860
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
    sd00025
    Location:80 → 99
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    sd00029
    Location:415 → 434
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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