ulk2 unc-51 like autophagy activating kinase 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ulk2provided by ZNC
Official Full Name: unc-51 like autophagy activating kinase 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-090218-30
See related: Ensembl:ENSDARG00000097205 AllianceGenome:ZFIN:ZDB-GENE-090218-30
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:7164951
Summary: Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within dendrite arborization; habenula development; and regulation of dendrite morphogenesis. Predicted to be active in autophagosome; cytosol; and phagophore assembly site membrane. Is expressed in habenula; hatching gland; polster; sensory system; and trigeminal placode. Orthologous to human ULK2 (unc-51 like autophagy activating kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 15

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (20843399..20893599)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (20907433..20959044)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ulk2, which interacts with Kctd12 proteins via a small proline-serine rich domain, promotes branching and elaboration of dendrites
Title: Kctd12 and Ulk2 partner to regulate dendritogenesis and behavior in the habenular nuclei.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

fa96g10.y1 (e-PCR)
- UniSTS:189735

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon extension	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within dendrite arborization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within habenula development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within habenula development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of collateral sprouting	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in piecemeal microautophagy of the nucleus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of autophagy	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of autophagy	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of dendrite morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in reticulophagy	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in autophagosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in phagophore assembly site	IBA Inferred from Biological aspect of Ancestor more info
is_active_in phagophore assembly site membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: serine/threonine-protein kinase ULK2

Names: unc-51-like kinase 2

XP_002664661.3

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007126.7 Reference GRCz11 Primary Assembly

Range

20843399..20893599

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_002664615.6 → XP_002664661.3 serine/threonine-protein kinase ULK2

UniProtKB/TrEMBL

A0A8M1RKN8, X1WEA3

Related

ENSDARP00000128554.1, ENSDART00000153726.2

Conserved Domains (3) summary

smart00220
Location:9 → 271

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam12063
Location:818 → 1025

DUF3543; Domain of unknown function (DUF3543)

cl21453
Location:2 → 272

PKc_like; Protein Kinases, catalytic domain