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ppfibp2a PPFIA binding protein 2a [ Danio rerio (zebrafish) ]

Gene ID: 100317962, updated on 17-Sep-2024

Summary

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Official Symbol
ppfibp2aprovided by ZNC
Official Full Name
PPFIA binding protein 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070705-277
See related
Ensembl:ENSDARG00000061977 AllianceGenome:ZFIN:ZDB-GENE-070705-277
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-105j11.1; si:dkey-105j11.2
Summary
Predicted to be involved in neuromuscular junction development. Predicted to be active in presynaptic active zone. Orthologous to human PPFIBP2 (PPFIA binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See ppfibp2a in Genome Data Viewer
Location:
chromosome: 18
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (29145868..29192049)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (29166918..29213795)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene synaptotagmin IXa Neighboring gene uncharacterized LOC137488292 Neighboring gene uncharacterized LOC137488293 Neighboring gene MAF bZIP transcription factor a Neighboring gene uncharacterized LOC137488233

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Molecular evolution and functional divergence of zebrafish (Danio rerio) cryptochrome genes. Liu C, et al. Sci Rep, 2015 Jan 29. PMID 25630924, Free PMC Article
  2. Eumetazoan cryptochrome phylogeny and evolution. Haug MF, et al. Genome Biol Evol, 2015 Jan 18. PMID 25601102, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in neuromuscular junction development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in presynaptic active zone IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
liprin-beta-2
Names
PTPRF interacting protein, binding protein 2a (liprin beta 2)
protein tyrosine phosphatase, receptor-type, F interacting protein, binding protein 2a

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    29145868..29192049
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005159197.4 → XP_005159254.1  liprin-beta-2 isoform X2

    UniProtKB/TrEMBL
    A0A8M2B662, F1QBQ0
    Related
    ENSDARP00000083464.4, ENSDART00000089031.6
    Conserved Domains (5) summary
    cd09563
    Location:502 → 565
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:576 → 638
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:661 → 732
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    smart00454
    Location:502 → 566
    SAM; Sterile alpha motif
    cl23765
    Location:135 → 233
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  2. XM_068214912.1 → XP_068071013.1  liprin-beta-2 isoform X1

  3. XM_068214913.1 → XP_068071014.1  liprin-beta-2 isoform X3

  4. XM_009293643.3 → XP_009291918.1  liprin-beta-2 isoform X5

    See identical proteins and their annotated locations for XP_009291918.1

    UniProtKB/TrEMBL
    A0A8M3AKG5
    Conserved Domains (5) summary
    cd09563
    Location:423 → 486
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:497 → 559
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:582 → 653
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    smart00454
    Location:423 → 487
    SAM; Sterile alpha motif
    cl23765
    Location:56 → 154
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  5. XM_068214914.1 → XP_068071015.1  liprin-beta-2 isoform X4

    Related
    ENSDARP00000119447.2, ENSDART00000135633.3
Nucleotide Protein Strain
Heading Accession and Version

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