Mir181c microRNA 181c [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mir181cprovided by RGD
Official Full Name: microRNA 181cprovided by RGD
Primary source: RGD:2325381
See related: EnsemblRapid:ENSRNOG00000035569 miRBase:MI0000924; AllianceGenome:RGD:2325381
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: rno-mir-181c
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

Location:: 19q11

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (40888291..40888396)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (23983523..23983628)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (25290211..25290316, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-181c, a potential mediator for acute kidney injury in a burn rat model with following sepsis.
Title: miR-181c, a potential mediator for acute kidney injury in a burn rat model with following sepsis.
Trehalose Attenuates Learning and Memory Impairments in Aged Rats via Overexpression of miR-181c.
Title: Trehalose Attenuates Learning and Memory Impairments in Aged Rats via Overexpression of miR-181c.
Silencing interleukin 1alpha underlies a novel inhibitory role of miR-181c-5p in alleviating low-grade inflammation of rats with irritable bowel syndrome.
Title: Silencing interleukin 1α underlies a novel inhibitory role of miR-181c-5p in alleviating low-grade inflammation of rats with irritable bowel syndrome.
miR-181c participates in oxidative stress-mediated Bone mesenchymal stem cell damage by modulating the AMPK-Mfn1 signaling pathway.
Title: Pretreatment of bone mesenchymal stem cells with miR181-c facilitates craniofacial defect reconstruction via activating AMPK-Mfn1 signaling pathways.
These results demonstrated that miR-181c regulation of TNF-alpha expression plays a role in IL-6-induced beta cell apoptosis.
Title: MicroRNA-181c Inhibits Interleukin-6-mediated Beta Cell Apoptosis by Targeting TNF-α Expression.
miR-181c could promote the cell viability and inhibit the apoptosis of PC12 cells induced by MPP (+) by downregulating BCL2L11, which may play a protective role.
Title: MicroRNA-181c functions as a protective factor in a 1-methyl-4-phenylpyridinium iodide-induced cellular Parkinson's disease model via BCL2L11.
Results implicate the small non-coding miR-181c in neuronal morphology, and provide a framework of understanding how dysregulation of a neurodevelopmentally relevant miR in the amygdala may contribute to the pathophysiology of autism spectrum disorders.
Title: Elevated microRNA-181c and microRNA-30d levels in the enlarged amygdala of the valproic acid rat model of autism.
TLR4 expression was inhibited by miR-181c binding to its 3'UTR site.
Title: MicroRNA-181c negatively regulates the inflammatory response in oxygen-glucose-deprived microglia by targeting Toll-like receptor 4.
miRNA delivered to the heart in-vivo can lead to cardiac dysfunction by regulating mitochondrial genes
Title: miR-181c regulates the mitochondrial genome, bioenergetics, and propensity for heart failure in vivo.
Nuclear miR-181c translocates into the heart mitochondria and regulates mitochondrial genome expression.
Title: Nuclear miRNA regulates the mitochondrial genome in the heart.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables mRNA base-pairing translational repressor activity	ISO Inferred from Sequence Orthology more info
enables single-stranded RNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hematopoietic stem cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in miRNA-mediated gene silencing by inhibition of translation	ISO Inferred from Sequence Orthology more info
involved_in miRNA-mediated gene silencing by mRNA destabilization	ISO Inferred from Sequence Orthology more info
involved_in miRNA-mediated post-transcriptional gene silencing	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of T cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of activated T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of interleukin-17 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of interleukin-7 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-7 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of synoviocyte proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulatory ncRNA-mediated gene silencing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception of sound	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of RISC complex	ISO Inferred from Sequence Orthology more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.