Mir19a microRNA 19a [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mir19aprovided by RGD
Official Full Name: microRNA 19aprovided by RGD
Primary source: RGD:2325462
See related: EnsemblRapid:ENSRNOG00000035578 miRBase:MI0000849; AllianceGenome:RGD:2325462
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: rno-mir-19a
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

Location:: 15q23

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (98588131..98588212)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (92180912..92180993)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (100180162..100180243)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibiting autophagy by miR-19a-3p/PTEN regulation protected retinal pigment epithelial cells from hyperglycemic damage.
Title: Inhibiting autophagy by miR-19a-3p/PTEN regulation protected retinal pigment epithelial cells from hyperglycemic damage.
Knockdown of miR-19a suppresses gastrointestinal dysmotility diarrhea after TBI by regulating VIP expression.
Title: Knockdown of miR-19a suppresses gastrointestinal dysmotility diarrhea after TBI by regulating VIP expression.
MicroRNA-19 upregulation attenuates cardiac fibrosis via targeting connective tissue growth factor.
Title: MicroRNA-19 upregulation attenuates cardiac fibrosis via targeting connective tissue growth factor.
Inhibition of microRNA-19a-3p alleviates the neuropathic pain (NP) in rats after chronic constriction injury (CCI) via targeting KLF7.
Title: Inhibition of microRNA-19a-3p alleviates the neuropathic pain (NP) in rats after chronic constriction injury (CCI) via targeting KLF7.
miR-19a/b-3p promotes inflammation during cerebral ischemia/reperfusion injury via SIRT1/FoxO3/SPHK1 pathway.
Title: miR-19a/b-3p promotes inflammation during cerebral ischemia/reperfusion injury via SIRT1/FoxO3/SPHK1 pathway.
MicroRNA-19a attenuates hypoxia-induced cardiomyocyte apoptosis by downregulating NHE-1 expression and decreasing calcium overload.
Title: MicroRNA-19a attenuates hypoxia-induced cardiomyocyte apoptosis by downregulating NHE-1 expression and decreasing calcium overload.
MiR-19a suppress apoptosis of myocardial cells in rats with myocardial ischemia/reperfusion through PTEN/Akt/P-Akt signaling pathway.
Title: MiR-19a suppress apoptosis of myocardial cells in rats with myocardial ischemia/reperfusion through PTEN/Akt/P-Akt signaling pathway.
LncRNA NEAT1 promotes cardiac hypertrophy through microRNA-19a-3p/SMYD2 axis.
Title: LncRNA NEAT1 promotes cardiac hypertrophy through microRNA-19a-3p/SMYD2 axis.
Human umbilical cord mesenchymal stem cells-derived exosomes transfers microRNA-19a to protect cardiomyocytes from acute myocardial infarction by targeting SOX6.
Title: Human umbilical cord mesenchymal stem cells-derived exosomes transfers microRNA-19a to protect cardiomyocytes from acute myocardial infarction by targeting SOX6.
miR19a promoted proliferation, migration and invasion via the MMP/aSMA/SM22a signaling pathway by inhibiting RHOB, suggesting that miR19a is a possible regulatory factor of RHOB.
Title: miR‑19a promotes vascular smooth muscle cell proliferation, migration and invasion through regulation of Ras homolog family member B.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables mRNA 3'-UTR binding	ISO Inferred from Sequence Orthology more info
enables mRNA base-pairing translational repressor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within B cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in cellular response to bacterial lipopeptide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung development	ISO Inferred from Sequence Orthology more info
involved_in miRNA-mediated gene silencing by mRNA destabilization	ISO Inferred from Sequence Orthology more info
involved_in miRNA-mediated post-transcriptional gene silencing	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of cardiac epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cellular response to transforming growth factor beta stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of extracellular matrix assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of fibroblast migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of inflammatory response to antigenic stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of matrix metallopeptidase secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of toll-like receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of B cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth involved in cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pre-B cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiac conduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spinal cord motor neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ventricular septum morphogenesis	ISO Inferred from Sequence Orthology more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.