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ADRB1 adrenoceptor beta 1 [ Meleagris gallopavo (turkey) ]

Gene ID: 100303680, updated on 8-Mar-2024

Summary

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Gene symbol
ADRB1
Gene description
adrenoceptor beta 1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Meleagris gallopavo
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Meleagridinae; Meleagris
Also known as
ADRB2
Annotation information
Annotation category: partial on reference assembly
Orthologs
human mouse all
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Genomic context

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See ADRB1 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
2
Annotation release Status Assembly Chr Location
103 current Turkey_5.1 (GCF_000146605.3) 8 NC_015018.2 (28488986..28491496)
Build 1.1 previous assembly Turkey_2.01 (GCF_000146605.1) 8 NC_015018.1 (30232432..30238545)

Chromosome 8 - NC_015018.2Genomic Context describing neighboring genes Neighboring gene actin filament associated protein 1 like 2 Neighboring gene tudor domain containing 1 Neighboring gene coiled-coil domain containing 186 Neighboring gene uncharacterized LOC109368951

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Breed-related differences in age-dependent down-regulation of the β1-adrenoceptor and adenylate cyclase activity in atrial and ventricular myocardium of Cröllwitzer ("wild-type") turkeys. Hoffmann S, et al. Poult Sci, 2018 Mar 1. PMID 29253207
  2. Backbone NMR reveals allosteric signal transduction networks in the β1-adrenergic receptor. Isogai S, et al. Nature, 2016 Feb 11. PMID 26840483
  3. The 2.1 Å resolution structure of cyanopindolol-bound β1-adrenoceptor identifies an intramembrane Na+ ion that stabilises the ligand-free receptor. Miller-Gallacher JL, et al. PLoS One, 2014. PMID 24663151, Free PMC Article
  4. Monoclonal anti-β1-adrenergic receptor antibodies activate G protein signaling in the absence of β-arrestin recruitment. Hutchings CJ, et al. MAbs, 2014 Jan-Feb. PMID 24253107, Free PMC Article
  5. The pharmacological effects of the thermostabilising (m23) mutations and intra and extracellular (β36) deletions essential for crystallisation of the turkey β-adrenoceptor. Baker JG, et al. Naunyn Schmiedebergs Arch Pharmacol, 2011 Jul. PMID 21547538, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In both sexes of Crollwitzer turkey hearts, the beta1-AR density decreased with age but significance was reached in male cardiac chambers.
    Title: Breed-related differences in age-dependent down-regulation of the β1-adrenoceptor and adenylate cyclase activity in atrial and ventricular myocardium of Cröllwitzer ("wild-type") turkeys.
  2. backbone NMR reveals allosteric signal transduction networks in the beta1-adrenergic receptor
    Title: Backbone NMR reveals allosteric signal transduction networks in the β1-adrenergic receptor.
  3. 2.1 A resolution structure of cyanopindolol-bound beta1-adrenoceptor identifies an intramembrane Na+ ion that stabilises the ligand-free receptor
    Title: The 2.1 Å resolution structure of cyanopindolol-bound β1-adrenoceptor identifies an intramembrane Na+ ion that stabilises the ligand-free receptor.
  4. Monoclonal anti-beta1-adrenergic receptor antibodies activate G protein signaling in the absence of beta-arrestin recruitment
    Title: Monoclonal anti-β1-adrenergic receptor antibodies activate G protein signaling in the absence of β-arrestin recruitment.
  5. Although the combination of mutations severely reduced the activation ability of ADRB1, the final crystallised receptor (beta36-m23) was still a functional receptor capable of binding agonists and antagonists and activating cellular agonist responses.
    Title: The pharmacological effects of the thermostabilising (m23) mutations and intra and extracellular (β36) deletions essential for crystallisation of the turkey β-adrenoceptor.
  6. four crystal structures of the thermostabilized turkey beta(1)-adrenergic receptor bound to the full agonists carmoterol and isoprenaline and the partial agonists salbutamol and dobutamine
    Title: The structural basis for agonist and partial agonist action on a β(1)-adrenergic receptor.
  7. The all-atom force-field energy function was used to calculate a stability score to detect stabilizing point mutations in G-protein coupled receptors.
    Title: Structural insights into conformational stability of wild-type and mutant beta1-adrenergic receptor.
  8. 2.7 A resolution crystal structure of turkey beta(1)-adrenergic receptor in complex with the high-affinity antagonist cyanopindolol
    Title: Structure of a beta1-adrenergic G-protein-coupled receptor.
  9. Molecular simulations of beta-1 AR show formation of an ionic lock, with the cytoplasmatic end of transmembrane (TM)6 helix approaching TM3 resulting in an equilibrium geometry that is stabilized by direct interaction of arginine and glutamate.
    Title: Observation of "ionic lock" formation in molecular dynamics simulations of wild-type beta 1 and beta 2 adrenergic receptors.
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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables beta1-adrenergic receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of heart rate by epinephrine-norepinephrine IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
beta-1 adrenergic receptor
Names
adrenergic, beta-1-, receptor
beta-1 adrenoceptor
beta-1 adrenoreceptor
beta-T
beta1-adrenergic G-protein-coupled receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303175.1 → NP_001290104.1  beta-1 adrenergic receptor

    See identical proteins and their annotated locations for NP_001290104.1

    Status: PROVISIONAL

    Source sequence(s)
    M14379
    UniProtKB/Swiss-Prot
    P07700
    UniProtKB/TrEMBL
    G1NEX5
    Conserved Domains (2) summary
    pfam00001
    Location:58 → 343
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:56 → 357
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Meleagris gallopavo Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Turkey_5.1 Primary Assembly

Genomic

  1. NC_015018.2 Reference Turkey_5.1 Primary Assembly

    Range
    28488986..28491496
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P07700.1 GenPept UniProtKB/Swiss-Prot:P07700

Gene LinkOut

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