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FTX FTX transcript, XIST regulator [ Homo sapiens (human) ]

Gene ID: 100302692, updated on 2-Nov-2024

Summary

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Official Symbol
FTXprovided by HGNC
Official Full Name
FTX transcript, XIST regulatorprovided by HGNC
Primary source
HGNC:HGNC:37190
See related
Ensembl:ENSG00000230590 MIM:300936; AllianceGenome:HGNC:37190
Gene type
ncRNA
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LINC00182; MIR374AHG; NCRNA00182
Summary
This gene is located upstream of XIST, within the X-inactivation center (XIC). It produces a spliced long non-coding RNA that is thought to positively regulate the expression of XIST, which is essential for the initiation and spread of X-inactivation. [provided by RefSeq, May 2015]
Expression
Ubiquitous expression in ovary (RPKM 3.1), thyroid (RPKM 2.1) and 25 other tissues See more
Orthologs
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Genomic context

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See FTX in Genome Data Viewer
Location:
Xq13.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (74028136..74293574, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (72461681..72727079, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (73247971..73513409, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29763 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:73071267-73071768 Neighboring gene TSIX transcript, XIST antisense RNA Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:73083465-73084112 Neighboring gene X inactive specific transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:73134838-73135338 Neighboring gene FXYD domain containing ion transport regulator 6 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29765 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:73185196-73185760 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chrX:73186327-73186890 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chrX:73197425-73197984 Neighboring gene JPX transcript, XIST activator Neighboring gene ribosomal protein SA pseudogene 14 Neighboring gene SHISA5 pseudogene 2 Neighboring gene AARSD1 pseudogene 1 Neighboring gene ubiquitin like with PHD and ring finger domains 2 pseudogene 1 Neighboring gene DEAD-box helicase 3 pseudogene 1 Neighboring gene DEAD-box helicase 3 pseudogene 2 Neighboring gene ATP5MK pseudogene 1 Neighboring gene makorin ring finger protein 5, pseudogene Neighboring gene RAB11 family interacting protein 1 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:73441998-73442498 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:73442499-73442999 Neighboring gene BMP2 inducible kinase like (pseudogene) Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:73469676-73470236 Neighboring gene microRNA 374b Neighboring gene microRNA 374c Neighboring gene microRNA 421 Neighboring gene RNA, 7SL, cytoplasmic 648, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:73503545-73504154 Neighboring gene uncharacterized LOC124905199 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chrX:73510290-73511081 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:73511873-73512663 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:73544829-73545594 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:73545595-73546361 Neighboring gene microRNA 374a Neighboring gene microRNA 545 Neighboring gene zinc finger CCHC-type containing 13 Neighboring gene NSL1, MIND kinetochore complex component, homolog (S. cerevisiae) pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Quantitative Proteomics Analysis Reveals the Potential Role of lncRNA FTX in Endothelial Cells. Zhao Q, et al. Front Biosci (Landmark Ed), 2024 Jan 18. PMID 38287828
  2. Biological significance of long non-coding RNA FTX expression in human colorectal cancer. Guo XB, et al. Int J Clin Exp Med, 2015. PMID 26629053, Free PMC Article
  3. Emerging roles of long non-coding RNA FTX in human disorders. Sheykhi-Sabzehpoush M, et al. Clin Transl Oncol, 2023 Oct. PMID 37095425
  4. Knockdown of Long Noncoding RNA FTX Inhibits Proliferation, Migration, and Invasion in Renal Cell Carcinoma Cells. He X, et al. Oncol Res, 2017 Jan 26. PMID 27983937, Free PMC Article
  5. Prognostic significance of long non-coding RNA five prime to XIST in various cancers. Zhou J, et al. BMC Cancer, 2022 Jan 13. PMID 35027040, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mechanism of LncRNA FTX regulates nephroblastoma progression through MiR-215-5p/PI3K/AKT axis.
    Title: Mechanism of LncRNA FTX regulates nephroblastoma progression through MiR-215-5p/PI3K/AKT axis.
  2. Quantitative Proteomics Analysis Reveals the Potential Role of lncRNA FTX in Endothelial Cells.
    Title: Quantitative Proteomics Analysis Reveals the Potential Role of lncRNA FTX in Endothelial Cells.
  3. Long noncoding RNA FTX promotes epithelial-mesenchymal transition of epithelial ovarian cancer through modulating miR-7515/TPD52 and activating Met/Akt/mTOR.
    Title: Long noncoding RNA FTX promotes epithelial-mesenchymal transition of epithelial ovarian cancer through modulating miR-7515/TPD52 and activating Met/Akt/mTOR.
  4. Emerging roles of long non-coding RNA FTX in human disorders.
    Title: Emerging roles of long non-coding RNA FTX in human disorders.
  5. The pluripotent factor OCT4A enhances the self-renewal of human dental pulp stem cells by targeting lncRNA FTX in an LPS-induced inflammatory microenvironment.
    Title: The pluripotent factor OCT4A enhances the self-renewal of human dental pulp stem cells by targeting lncRNA FTX in an LPS-induced inflammatory microenvironment.
  6. Overexpressed lncRNA FTX promotes the cell viability, proliferation, migration and invasion of renal cell carcinoma via FTX/miR4429/UBE2C axis.
    Title: Overexpressed lncRNA FTX promotes the cell viability, proliferation, migration and invasion of renal cell carcinoma via FTX/miR‑4429/UBE2C axis.
  7. Prognostic significance of long non-coding RNA five prime to XIST in various cancers.
    Title: Prognostic significance of long non-coding RNA five prime to XIST in various cancers.
  8. Long non-coding RNA (lncRNA) five prime to Xist (FTX) promotes retinoblastoma progression by regulating the microRNA-320a/with-no-lysine kinases 1 (WNK1) axis.
    Title: Long non-coding RNA (lncRNA) five prime to Xist (FTX) promotes retinoblastoma progression by regulating the microRNA-320a/with-no-lysine kinases 1 (WNK1) axis.
  9. Long non-coding RNA FTX predicts a poor prognosis of human cancers: a meta-analysis.
    Title: Long non-coding RNA FTX predicts a poor prognosis of human cancers: a meta-analysis.
  10. The Function of LncRNA FTX in Several Common Cancers.
    Title: The Function of LncRNA FTX in Several Common Cancers.
Submit: New GeneRIF Correction See all GeneRIFs (23)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Other Names

  • FTX transcript, XIST regulator (non-protein coding)
  • five prime to XIST
  • mir-374a-545 cluster host gene (non-protein coding)

Clone Names

  • FLJ18387

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_028379.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004386, AL139400
    Related
    ENST00000602812.6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    74028136..74293574 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    72461681..72727079 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Chemical Information
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Research Materials