U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

IL4 interleukin 4 [ Oryctolagus cuniculus (rabbit) ]

Gene ID: 100302454, updated on 8-Mar-2024

Summary

Go to the top of the page Help
Gene symbol
IL4
Gene description
interleukin 4
See related
Ensembl:ENSOCUG00000011943
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Oryctolagus cuniculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Also known as
IL2; BSF-1
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See IL4 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) 3 NC_067376.1 (15655971..15664347)

Chromosome 3 - NC_067376.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC127490677 Neighboring gene interleukin 13 Neighboring gene small nucleolar RNA SNORA64/SNORA10 family Neighboring gene kinesin family member 3A

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_067376.1 Chromosome 3 Reference UM_NZW_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The complete cDNA sequences of IL-2, IL-4, IL-6 AND IL-10 from the European rabbit (Oryctolagus cuniculus). Perkins HD, et al. Cytokine, 2000 Jun. PMID 10843729
  2. Genetic characterization of interleukins (IL-1α, IL-1β, IL-2, IL-4, IL-8, IL-10, IL-12A, IL-12B, IL-15 and IL-18) with relevant biological roles in lagomorphs. Neves F, et al. Innate Immun, 2015 Nov. PMID 26395994, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables interleukin-4 receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in B cell costimulation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in T-helper 2 cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in activation of Janus kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in innate immune response in mucosa IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in microglial cell activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in myeloid dendritic cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of T-helper 17 cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of acute inflammatory response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of chronic inflammatory response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of complement-dependent cytotoxicity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of endothelial cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of epithelial cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of macrophage activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of MHC class II biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of T cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of amyloid-beta clearance IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of defense response to virus by host IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of eosinophil chemotaxis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of interleukin-10 production IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of interleukin-13 production IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of isotype switching to IgE isotypes IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of isotype switching to IgG isotypes IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of macroautophagy IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of mast cell degranulation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of mononuclear cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of myoblast fusion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of receptor-mediated endocytosis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of tyrosine phosphorylation of STAT protein IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
interleukin-4
Names
B-cell stimulatory factor 1
interleukin 4 variant IL-4delta3
interleukin 4 variant IL-4int2A
interleukin 4 variant IL-4int3A
interleukin 4 variant IL-4int3B
lymphocyte stimulatory factor 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163177.1 → NP_001156649.1  interleukin-4 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001156649.1

    Status: PROVISIONAL

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    EF606761
    UniProtKB/Swiss-Prot
    Q0MS70, Q9MZR8
    UniProtKB/TrEMBL
    A0A0N9HKQ5, A0A0N9HNN8, A0A0N9HS77, A0A0N9HSC4, A5Z1F6
    Related
    ENSOCUP00000025135.2, ENSOCUT00000024099.2
    Conserved Domains (1) summary
    pfam00727
    Location:28 → 143
    IL4; Interleukin 4

  2. NM_001171106.1 → NP_001164577.1  interleukin-4 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001164577.1

    Status: PROVISIONAL

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region compared to variant 1. The encoded protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AF169170
    UniProtKB/TrEMBL
    G1U6T7, Q9MZR7
    Related
    ENSOCUP00000038204.1, ENSOCUT00000037091.1
    Conserved Domains (1) summary
    pfam00727
    Location:28 → 127
    IL4; Interleukin 4

RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UM_NZW_1.0 Primary Assembly

Genomic

  1. NC_067376.1 Reference UM_NZW_1.0 Primary Assembly

    Range
    15655971..15664347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9MZR8.1 GenPept UniProtKB/Swiss-Prot:Q9MZR8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.